ETIOLOGY OF AGE-ASSOCIATED ANEUPLOIDY - A MECHANISM-BASED ON THE FREE-RADICAL THEORY OF AGING

被引：106
作者：
TARIN, JJ
机构：
[1] Department of Paediatrics, Obstetrics, and Gynaecology, Faculty of Medicine, University of Valencia, 46010 Valencia
来源：
HUMAN REPRODUCTION | 1995年 / 10卷 / 06期
关键词：
AGE; ANEUPLOIDY; FREE RADICAL; OXIDATIVE STRESS;
D O I：
10.1093/HUMREP/10.6.1563
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
A general model is put forward to explain the mechanism by which age-associated aneuploidies are produced. This is based on the free radical theory of ageing, which assumes a rise in oxidative stress with age. It is proposed that determination of indicators of oxidative stress in oocytes from various sources Could be a first step in the testing of this hypothesis.
引用
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页码：1563 / 1565
页数：3
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