SYNTHESIS OF MORPHINE-6-GLUCURONIDE VIA A HIGHLY SELECTIVE ENZYME-CATALYZED HYDROLYSIS REACTION

被引：15

作者：

BROWN, RT

CARTER, NE

SCHEINMANN, F

TURNER, NJ

机构：

[1] UNIV MANCHESTER, DEPT CHEM, MANCHESTER M13 9PL, LANCS, ENGLAND

[2] ULTRAFINE CHEM, MANCHESTER M15 6SY, LANCS, ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 07期

关键词：

D O I：

10.1016/0040-4039(94)02409-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Morphine-6-glucuronide 1, a patent analgesic, has been prepared from morphine-3,6-diglucuronide 3 via a highly selective hydrolytic cleavage of the phenolic 3-glucuronide group using beta-glucuronidase as catalyst.

引用

页码：1117 / 1120

页数：4

共 6 条

[1]

BROWN RT, 1993, Patent No. 3051

[2]

OSBORNE R, 1988, LANCET, V1, P828

[3]

OSBORNE RJ, 1987, BRIT J CANCER, V56, P227

[4]

SAWE J, 1982, ACTA ANAESTH SCAND, V26, P47

[5] ENZYME-CATALYZED SYNTHESIS OF CARBOHYDRATES [J].

TOONE, EJ ;

SIMON, ES ;

BEDNARSKI, MD ;

WHITESIDES, GM .

TETRAHEDRON, 1989, 45 (17) :5365-5422

[6] STEREOSPECIFIC ATTACHMENT OF CARBOHYDRATES TO AMINO-ACID DERIVATIVES USING BETA-GLUCOSIDASE AND BETA-XYLOSIDASE [J].

TURNER, NJ ;

WEBBERLEY, MC .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (19) :1349-1350

← 1 →