EFFECT OF CORTICOSTEROIDS FOR FETAL MATURATION ON PERINATAL OUTCOMES

被引：739

作者：

GILSTRAP, LC

CHRISTENSEN, R

CLEWELL, WH

DALTON, ME

DAVIDSON, EC

ESCOBEDO, MB

GJERDINGEN, DK

GODDARDFINEGOLD, J

GOLDENBERG, RK

GRIMES, DA

HANSEN, TN

KAUFFMAN, RE

KEELER, EB

OH, W

SUSMAN, EJ

VOGEL, MG

AVERY, ME

BALLARD, PL

BALLARD, RA

CROWLEY, P

GARITE, T

GOLDENBERG, RL

HANKINS, GDV

JOBE, AH

KOPPE, JG

MAHER, JE

MERKATZ, IR

SHANKARAN, S

SIMPSON, KN

SINCLAIR, JC

SLOTKIN, TA

TAEUSCH, HW

WRIGHT, LL

ALEXANDER, D

BERBERICH, MA

BRACKEN, M

COOPER, L

CULPEPPER, L

ELLIOTT, JM

FERGUSON, JH

FRIGOLETTO, F

GAIL, DB

HALL, WH

JONES, MD

MEDOFFCOOPER, B

MERENSTEIN, GB

WHALEN, JM

机构：

[1] UNIV FLORIDA,COLL MED,GAINESVILLE,FL

[2] PHOENIX PERINATAL ASSOCIATES,DEPT MATERNAL FETAL MED,PHOENIX,AZ

[3] TUFTS UNIV,NEW ENGLAND MED CTR,DEPT OBSTET & GYNECOL,BOSTON,MA 02111

[4] MARTIN LUTHER KING JR CHARLES R DREW UNIV,LOS ANGELES,CA

[5] UNIV TEXAS,HLTH SCI CTR,DIV NEONATOL,SAN ANTONIO,TX

[6] UNIV MINNESOTA,DEPT FAMILY PRACTICE & COMMUNITY HLTH,ST PAUL,MN 55108

[7] BAYLOR COLL MED,DEPT PEDIAT & PATHOL,DIV PEDIAT NEUROL,HOUSTON,TX 77030

[8] UNIV ALABAMA,SCH MED,CTR OBSTET RES,BIRMINGHAM,AL

[9] UNIV ALABAMA,SCH MED,DEPT OBSTET & GYNECOL,BIRMINGHAM,AL

[10] BAYLOR COLL MED,DEPT PEDIAT,HOUSTON,TX 77030

[11] WAYNE STATE UNIV,CHILDRENS HOSP MICHIGAN,DEPT PEDIAT & PHARMACOL,DETROIT,MI

[12] RAND CORP,DEPT SOCIAL POLICY,SANTA MONICA,CA 90406

[13] BROWN UNIV,WOMEN & INFANTS HOSP,SCH MED,DEPT PEDIAT,PROVIDENCE,RI

[14] PENN STATE UNIV,BIOBEHAV HLTH PROGRAM,UNIVERSITY PK,PA 16802

[15] SCH DIST HATBORO HORSHAM,ELKINS PK,PA

[16] NICHHD,BETHESDA,MD 20892

[17] UNIV PENN,SCH MED,DEPT PEDIAT,DIV NEONATOL,PHILADELPHIA,PA 19104

[18] CHILDRENS HOSP PHILADELPHIA,PHILADELPHIA,PA 19104

[19] NHLBI,DIV LUNG DIS,CELL & DEV BIOL BRANCH,BETHESDA,MD 20892

[20] YALE UNIV,DEPT EPIDEMIOL & PUBL HLTH,NEW HAVEN,CT 06520

[21] NINR,DIV EXTRAMURAL PROGRAMS,BETHESDA,MD

[22] BROWN UNIV,MEM HOSP RHODE ISL,DEPT FAMILY MED,PAWTUCKET,RI 02860

[23] NIH,OFF MED APPLICAT RES,BETHESDA,MD 20892

[24] MASSACHUSETTS GEN HOSP,VINCENT MEM HOSP,DIV OBSTET,BOSTON,MA 02114

[25] UNIV TEXAS,SW MED CTR,DEPT OBSTET & GYNECOL,DALLAS,TX 75235

[26] UNIV CALIF LOS ANGELES,HARBOR MED CTR,SCH MED,WALTER P MARTIN RES CTR,TORRANCE,CA 90509

[27] UNIV COLORADO,SCH MED,DEPT PEDIAT,DENVER,CO

[28] CHILDRENS HOSP,DENVER,CO 80218

[29] UNIV PENN,SCH NURSING,PHILADELPHIA,PA 19104

[30] UNIV COLORADO,CHILDRENS HOSP,SCH MED,DEPT PEDIAT,DENVER,CO 80202

[31] NICHHD,OFF SCI POLICY & ANAL,BETHESDA,MD 20892

[32] NICHHD,CTR RES MOTHERS & CHILDREN,BETHESDA,MD 20892

来源：

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1995年 / 273卷 / 05期

关键词：

D O I：

10.1001/jama.1995.03520290065031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective.-To develop a consensus on the use of antenatal corticosteroids for fetal maturation in preterm infants. Participants.-A nonfederal, nonadvocate, 16-member consensus panel including representatives from neonatology, obstetrics, family medicine, behavioral medicine, psychology, biostatistics, and the public; 19 experts in neonatology, obstetrics, and pharmacology presented data to the consensus panel and a conference audience of approximately 500. Evidence.-An extensive bibliography of references was produced for the consensus panel and the conference audience using a variety of on-line databases including MEDLINE. The consensus panel met several times prior to the conference to review the literature. It also commissioned an updated meta-analysis, a neonatal registry review, and an economic analysis that were presented at the conference. The experts prepared abstracts for distribution at the conference, presented data, and answered questions from the panel and audience. The panel evaluated the strength of the scientific evidence using the grading system developed by the Canadian Task Force on the Periodic Health Examination and adapted by the US Preventive Services Task Force, Consensus.-The consensus panel, answering predefined consensus questions, developed their conclusions based on the scientific evidence presented in open forum and the scientific literature. Consensus Statement.-The consensus panel composed a draft statement that was read in its entirety at the conference for comment. The panel released a revised statement at the end of the conference and finalized the revisions a few weeks after the conference. Conclusions.-Antenatal corticosteroid therapy is indicated for women at risk of premature delivery with few exceptions and will result in a substantial decrease in neonatal morbidity and mortality, as well as substantial savings in health care costs, The use of antenatal corticosteroids for fetal maturation is a rare example of a technology that yields substantial cost savings in addition to improving health.

引用

页码：413 / 418

页数：6