PRESSOR EFFECT OF NG-MONOMETHYL-L-ARGININE IN SHRSP

被引：20
作者：
AISAKA, K
MITANI, A
KITAJIMA, Y
ISHIHARA, T
机构：
[1] Laboratory of Experimental Pharmacolgy, Suntory Institute for Biomedical Research, Osaka, Mishima-gun
[2] Gene Technology, Suntory Institute for Biomedical Research, Osaka, Mishima-gun
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1990年 / 54卷 / 04期
关键词：
D O I：
10.1254/jjp.54.461
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pressor effects of NG-monomethyl-L-arginine (L-NMMA), a selective inhibitor of nitric oxide production from L-arginine, on mean blood pressure (MBP) were investigated in conscious Wistar Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). L-NMMA (0.1-10 mg/kg, i.v.) elicited a dose-dependent increase in the MBP of WKY and SHRSP. The pressor response to L-NMMA was more marked in SHRSP than in WKY. These results suggest that nitric oxide may play an important role in the blood pressure regulation in the conscious SHRSP. © 1990, The Japanese Pharmacological Society. All rights reserved.
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收藏
页码：461 / 463
页数：3
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