A case of spontaneous regression of pulmonary mucosa-associated lymphoid tissue (MALT) type lymphoma with Sjogren's syndrome treated with methotrexate for rheumatoid arthritis

被引：3

作者：

Yasui, Hideki ^{[1
]}

Nakamura, Yutaro ^{[1
]}

Hasegawa, Hirotsugu ^{[2
]}

Fujisawa, Tomoyuki ^{[1
]}

Enomoto, Noriyuki ^{[1
]}

Inui, Naoki ^{[1
]}

Fukuoka, Junya ^{[3
]}

Suda, Takafumi ^{[1
]}

机构：

[1] Hamamatsu Univ, Sch Med, Div 2, Dept Internal Med, 1-20-1 Handayama Higashi, Hamamatsu, Shizuoka 4313192, Japan

[2] Seirei Mikatahara Gen Hosp, Dept Resp Med, Hamamatsu, Shizuoka, Japan

[3] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pathol, Nagasaki, Japan

来源：

RESPIRATORY MEDICINE CASE REPORTS | 2015年 / 15卷

关键词：

Rheumatoid arthritis; Sjogren's syndrome; Methotrexate; Pulmonary mucosa-associated lymphoid; tissue type lymphoma; Spontaneous regression;

D O I：

10.1016/j.rmcr.2015.02.008

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

A 72-year-old man who had suffered from rheumatoid arthritis (RA) and Sjogren's syndrome (Sjs) since he was 66 years of age had been treated with methotrexate (MTX) for six years. He presented with a cough, sputum and dyspnea on exertion, and computed tomography findings showed multiple ground-glass opacities in both of his lungs. A biopsy of the lungs revealed low-grade mucosa-associated lymphoid tissue (MALT) type B-cell non-Hodgkin's lymphoma. Spontaneous complete remission of the lymphoma was achieved six months after withdrawing immune suppression with MTX. To our knowledge, no previous cases of spontaneous regression of pulmonary MALT-type lymphoma with Sjs treated with MTX for RA have been reported. Patients on MTX who are being treated for RA should be carefully monitored, especially when they have been diagnosed with coexistent Sjs. (C) 2015 The Authors. Published by Elsevier Ltd.

引用

页码：4 / 6

页数：3

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