MALFORMIN-C, A NEW METABOLITE OF ASPERGILLUS-NIGER

被引：55

作者：

ANDEREGG, RJ ^{[1
]}

BIEMANN, K ^{[1
]}

BUCHI, G ^{[1
]}

CUSHMAN, M ^{[1
]}

机构：

[1] MIT, DEPT CHEM, CAMBRIDGE, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1976年 / 98卷 / 11期

关键词：

D O I：

10.1021/ja00427a051

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A strain of A. niger collected from mold damaged rice produces malformin C, a new, highly toxic metabolite. It was established to be the disulfide of cyclo-D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-leucyl. Amino acid sequencing was accomplished using gas chromatographic mass spectrometry. A 100-m capillary gas chromatographic column allowed the separation of 2 diastereomeric N-trifluoroacetyl dipeptide methyl esters and the chirality of a critical L-valyl-D-leucyl dipeptide was determined with the aid of this method.

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页码：3365 / 3370

页数：6

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