HUMORAL AND CELL-MEDIATED IMMUNE-RESPONSES IN HEALTHY-CHILDREN AFTER ONE OR 2 DOSES OF VARICELLA VACCINE

被引：56

作者：

WATSON, B ^{[1
]}

BOARDMAN, C ^{[1
]}

LAUFER, D ^{[1
]}

PIERCY, S ^{[1
]}

TUSTIN, N ^{[1
]}

OLALEYE, D ^{[1
]}

CNAAN, A ^{[1
]}

STARR, SE ^{[1
]}

机构：

[1] CHILDRENS HOSP PHILADELPHIA,DEPT PEDIAT,DIV BIOSTAT & EPIDEMIOL,PHILADELPHIA,PA

来源：

CLINICAL INFECTIOUS DISEASES | 1995年 / 20卷 / 02期

关键词：

D O I：

10.1093/clinids/20.2.316

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study compared the immune responses of healthy children to one or two doses of Oka/Merck varicella vaccine. Both cell-mediated and humoral immune responses were significantly stronger 1 year later among children given two doses 3 months apart than among those given a single dose. Long-term follow-up studies are needed to determine whether two doses of vaccine indeed provide more complete and more durable protection than a single dose against breakthrough varicella in healthy children.

引用

页码：316 / 319

页数：4

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