SYNTHESIS AND TRITIUM LABELING OF THE HIGHLY POTENT MAST CELL-DEGRANULATING SUBSTANCE-P ANALOG H-ARG-PRO-LYS-PRO-NH-C12H25

被引：4

作者：

BIENERT, M ^{[1
]}

OEHLKE, J ^{[1
]}

MITTAG, E ^{[1
]}

NIEDRICH, H ^{[1
]}

机构：

[1] CENT INST NUCL RES,ROSSENDORF,GERMANY

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1990年 / 28卷 / 12期

关键词：

D O I：

10.1002/jlcr.2580281207

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Tritium labeling of the mast cell degranulating substance P analog H‐Arg‐Pro‐Lys(3,4‐3H‐Pro)‐NH‐C12H25 by catalytic saturation of the dehydroproline (Dhp ) double bond is described. Catalytic tritiation in water afforded the radioactive analog with a specific activity of 1.07 TBq/mmol. Tenfold enhancement of the catalyst‐to‐substrate ratio resulted in a reduced specific activity of 0.74 TBq/mmol. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：1401 / 1409

页数：9

共 14 条

[1] SYNTHESE DE LA L-ARGINYL-L-PROLYL-L-PROLYL-GLYCYL-L-PHENYLALANYL-L-SERYL-L-PROLYL-L-PHENYLALANYL-L-ARGININE, UN NONAPEPTIDE PRESENTANT LES PROPRIETES DE LA BRADYKININE [J].