COMPUTER-ASSISTED INTERPRETATION OF H-1-NMR SPECTRA IN THE ANALYSIS OF THE STRUCTURE OF OLIGOSACCHARIDES

被引：20

作者：

HOUNSELL, EF ^{[1
]}

WRIGHT, DJ ^{[1
]}

机构：

[1] NORTHWICK PK HOSP & CLIN RES CTR,HARROW HA1 3UJ,MIDDX,ENGLAND

来源：

CARBOHYDRATE RESEARCH | 1990年 / 205卷

关键词：

D O I：

10.1016/0008-6215(90)80124-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A computer program that can be implemented on IBM compatible microcomputers has been used to interpret the 1H-n.m.r. spectra of a series of mucin-derived alditols. The program compares the chemical shifts of resonances in the spectra of unknown oligosaccharides with those in a standard library constructed from data in the literature. The program then compiles the identified sequences into possible structures, which, together with a second component of the program from which the individual assignments of chemical shifts can be made, facilitates ready access to the literature data for final confirmation of the structures. © 1990.

引用

页码：19 / 29

页数：11

共 38 条

[1] APPLICATION OF MICROCOMPUTERS TO THE INTERPRETATION OF HIGH-RESOLUTION NUCLEAR MAGNETIC-RESONANCE SPECTRA OF ASPARAGINE-LINKED OLIGOSACCHARIDES - EVALUATION OF HIGH-MANNOSE STRUCTURES [J].

ANDERSON, DR ;

GRIMES, WJ .

ANALYTICAL BIOCHEMISTRY, 1985, 146 (01) :13-22

[2]

BERMAN E, 1985, CARBOHYD RES, V176, P1

[3] C-13 NUCLEAR MAGNETIC-RESONANCE DATA FOR OLIGOSACCHARIDES [J].

BOCK, K ;

PEDERSEN, C ;

PEDERSEN, H .

ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, 1984, 42 :193-225

[4] STRUCTURE OF SIALYL-OLIGOSACCHARIDES ISOLATED FROM BRONCHIAL MUCUS GLYCOPROTEINS OF PATIENTS (BLOOD GROUP-O) SUFFERING FROM CYSTIC-FIBROSIS [J].

BREG, J ;

VANHALBEEK, H ;

VLIEGENTHART, JFG ;

LAMBLIN, G ;

HOUVENAGHEL, MC ;

ROUSSEL, P .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1987, 168 (01) :57-68

[5] PRIMARY STRUCTURE OF NEUTRAL OLIGOSACCHARIDES DERIVED FROM RESPIRATORY-MUCUS GLYCOPROTEINS OF A PATIENT SUFFERING FROM BRONCHIECTASIS, DETERMINED BY COMBINATION OF 500-MHZ H-1-NMR SPECTROSCOPY AND QUANTITATIVE SUGAR ANALYSIS .2. STRUCTURE OF 19 OLIGOSACCHARIDES HAVING THE GLCNAC-BETA(1-]3)GALNAC-OL CORE (TYPE-3) OR THE GLCNAC-BETA(1-]3)[GLCNAC-BETA(1-]6)]GALNAC-OL CORE (TYPE-4E [J].

BREG, J ;

VANHALBEEK, H ;

VLIEGENTHART, JFG ;

KLEIN, A ;

LAMBLIN, G ;

ROUSSEL, P .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 171 (03) :643-654

[6]

DUA VK, 1986, J BIOL CHEM, V261, P1599

[7]

DUA VK, 1985, GLYCOCONJUGATE J, V2, P17

[8] EXPLORING NUCLEAR-SPIN SYSTEMS BY RELAYED MAGNETIZATION TRANSFER [J].

EICH, G ;

BODENHAUSEN, G ;

ERNST, RR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (13) :3731-3732

[9] COMPLETE H-1-NMR ASSIGNMENTS FOR 2 CORE-REGION OLIGOSACCHARIDES OF HUMAN MECONIUM GLYCOPROTEINS, USING 1D AND 2D METHODS AT 500 MHZ [J].

FEENEY, J ;

FRENKIEL, TA ;

HOUNSELL, EF .

CARBOHYDRATE RESEARCH, 1986, 152 :63-72

[10] CONFORMATIONAL TRANSITIONS IN N-LINKED OLIGOSACCHARIDES [J].

HOMANS, SW ;

DWEK, RA ;

BOYD, J ;

MAHMOUDIAN, M ;

RICHARDS, WG ;

RADEMACHER, TW .

BIOCHEMISTRY, 1986, 25 (20) :6342-6350

← 1 2 3 4 →