Visual prognosis and vitreous molecules after vitrectomy for macular edema with branch retinal vein occlusion

被引：10

作者：

Noma, Hidetaka ^{[1
]}

Funatsu, Hideharu ^{[1
]}

Mimura, Tatsuya ^{[2
]}

Eguchi, Shuichiro ^{[3
]}

Shimada, Katsunori ^{[4
]}

机构：

[1] Tokyo Womens Med Univ, Yachiyo Med Ctr, Dept Ophthalmol, 477-96,Owada Shinden, Yachiyo, Chiba 2768524, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Ophthalmol, Bunkyo Ku, Tokyo, Japan

[3] Eguchi Eye Hosp, Dept Ophthalmol, Hakodate, Hokkaido, Japan

[4] Tokyo Womens Med Univ, Dept Hyg & Publ Hlth II, Shinjuku Ku, Tokyo, Japan

来源：

CLINICAL OPHTHALMOLOGY | 2011年 / 5卷

关键词：

branch retinal vein occlusion; macular edema; vitrectomy; vascular endothelial growth factor; soluble intercellular adhesion molecule-1; pigment epithelium-derived factor;

D O I：

10.2147/OPTH.S16552

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

This study investigated whether vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), and pigment epithelium-derived factor (PEDF) influence the visual prognosis of patients with macular edema and branch retinal vein occlusion (BRVO). In 47 consecutive patients (47 eyes) undergoing vitrectomy, retinal thickness was examined by optical coherence tomography. Best-corrected visual acuity and the vitreous fluid levels of VEGF, sICAM-1, and PEDF were also determined. Patients were followed for at least 6 months after surgery. Vitreous fluid levels of VEGF and sICAM-1 were significantly lower in the patients with more marked improvement of visual acuity after vitrectomy, while PEDF was significantly higher. VEGF and sICAM-1 levels were significantly higher in patients with greater postoperative improvement of macular edema, while PEDF was significantly lower. In BRVO patients, vitreous fluid levels of VEGF, sICAM-1, and PEDF may influence both the response of macular edema to vitrectomy and the visual prognosis.

引用

页码：223 / 229

页数：7

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