DETERMINATION OF QUINIDINE, DIHYDROQUINIDINE, (3S)-3-HYDROXYQUINIDINE AND QUINIDINE N-OXIDE IN PLASMA AND URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：31
作者：
NIELSEN, F [1 ]
NIELSEN, KK [1 ]
BROSEN, K [1 ]
机构：
[1] ODENSE UNIV,DEPT CLIN PHARMACOL,DK-5000 ODENSE C,DENMARK
来源：
JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1994年 / 660卷 / 01期
关键词：
D O I：
10.1016/0378-4347(94)00259-2
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A specific and sensitive method for the quantitation of quinidine, (3S)-3-hydroxyquinidine, quinidine N-oxide, and dihydroquinidine in plasma and urine has been developed. The method is based on a single-step, liquid-liquid extraction procedure, followed by isocratic reversed-phase high-performance liquid chromatography, with fluorescence detection. After extraction from 250 mu l plasma and 100 mu l urine, the limit of determination is 10 nM and 25 nM, respectively. For the use as standards, commercially available quinidine was purified from dihydroquinidine; quinidine N-oxide was synthesized.
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页码：103 / 110
页数：8
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