TOPICAL FK506 - SUPPRESSION OF ALLERGIC AND IRRITANT CONTACT-DERMATITIS IN THE GUINEA-PIG

被引：36

作者：

LAUERMA, AI ^{[1
]}

STEIN, BD ^{[1
]}

HOMEY, B ^{[1
]}

LEE, CH ^{[1
]}

BLOOM, E ^{[1
]}

MAIBACH, HI ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT DERMATOL, BOX 0989, SURGE 110, SAN FRANCISCO, CA 94143 USA

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1994年 / 286卷 / 06期

关键词：

TOPICAL FK506; CONTACT DERMATITIS;

D O I：

10.1007/BF00402225

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Topical FK506 has recently been shown to have an anti-inflammatory effect in vivo in humans. In this study its effects in contact dermatitis were studied in the guinea pig model. Topical FK506 suppressed both irritant and allergic patch-test reactions. The most prominent suppressive effect was seen when skin sites were pretreated with FK506. Topical FK506 did not impair the induction of contact allergy as assessed by challenges, although it suppressed local lymph node cell accumulation during contact allergy induction. Topical FK506 may hold promise as a treatment for skin disorders that respond to oral FK506 or cyclosporin A.

引用

页码：337 / 340

页数：4

共 23 条

[1]

ABUELMAGD K, 1991, TRANSPLANT P, V23, P3322

[2] INTRALESIONAL CYCLOSPORINE FOR PSORIASIS - RELATIONSHIP OF DOSE, TISSUE-LEVELS, AND EFFICACY [J].

BURNS, MK ;

ELLIS, CN ;

EISEN, D ;

DUELL, E ;

GRIFFITHS, CEM ;

ANNESELEY, TM ;

HAMILTON, TA ;

BIRNBAUM, JE ;

VOORHEES, JJ .

ARCHIVES OF DERMATOLOGY, 1992, 128 (06) :786-790

[3] EFFECT OF TOPICAL CYCLOSPORINE RINSE ON ORAL LICHEN-PLANUS - A DOUBLE-BLIND ANALYSIS [J].

EISEN, D ;

ELLIS, CN ;

DUELL, EA ;

GRIFFITHS, CEM ;

VOORHEES, JJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (05) :290-294

[4]

GRIFFITHS CEM, 1987, LANCET, V1, P806

[5]

GROISSER DS, 1991, DERMATOL CLIN, V9, P805

[6]

HERMANN R C, 1988, Skin Pharmacology, V1, P246

[7] INTRALESIONAL CYCLOSPORINE IN THE TREATMENT OF PSORIASIS - A CLINICAL, IMMUNOLOGICAL, AND PHARMACOKINETIC STUDY [J].

HO, VC ;

GRIFFITHS, CEM ;

ELLIS, CN ;

GUPTA, AK ;

MCCUAIG, CC ;

NICKOLOFF, BJ ;

COOPER, KD ;

HAMILTON, TA ;

VOORHEES, JJ .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1990, 22 (01) :94-100

[8]

KNIGHT SC, 1988, TRANSPLANTATION, V46, pS48

[9] INHIBITION OF CONTACT ALLERGY REACTIONS BY TOPICAL FK506 [J].

LAUERMA, AI ;

MAIBACH, HI ;

GRANLUND, H ;

ERKKO, P ;

KARTAMAA, M ;

STUBB, S .

LANCET, 1992, 340 (8818) :556-556

[10]

LAUERMA AI, 1993, J INVEST DERMATOL, V100, P596

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