MOLECULAR-BIOLOGY OF THE RENIN-ANGIOTENSIN SYSTEM - IMPLICATIONS FOR HYPERTENSION AND BEYOND

被引：0
作者：
SAMANI, NJ [1 ]
机构：
[1] UNIV LEICESTER,DEPT MED,LEICESTER LE1 7RH,ENGLAND
来源：
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1991年 / 18卷
基金：
英国惠康基金;
关键词：
RENIN-ANGIOTENSIN SYSTEM; MOLECULAR BIOLOGY; HYPERTENSION; TISSUE RENIN-ANGIOTENSIN SYSTEMS; RENIN INHIBITORS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In the last decade, nucleic acid sequences coding for all three components of the renin-angiotensin cascade have been cloned. This has led to increased understanding of the transcriptional and translational regulation of renin, angiotensinogen, and angiotensin-converting enzyme (ACE). This review discusses the impact of the availability of these clones in three clinically relevant areas-the role of the renin-angiotensin system in hypertension, the role of tissue renin-angiotensin systems, and the development of renin inhibitors.
引用
收藏
页码：S1 / S6
页数：6
相关论文
共 50 条
  • [21] Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension
    Shim, Kwang Yong
    Eom, Young Woo
    Kim, Moon Young
    Kang, Seong Hee
    Baik, Soon Koo
    KOREAN JOURNAL OF INTERNAL MEDICINE, 2018, 33 (03) : 453 - 461
  • [22] Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis
    Capoulade, Romain
    Clavel, Marie-Annick
    Mathieu, Patrick
    Cote, Nancy
    Dumesnil, Jean G.
    Arsenault, Marie
    Bedard, Elisabeth
    Pibarot, Philippe
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2013, 43 (12) : 1262 - 1272
  • [23] Activation of Renin-Angiotensin System Induces Osteoporosis Independently of Hypertension
    Asaba, Yutaro
    Ito, Masako
    Fumoto, Toshio
    Watanabe, Ken
    Flikuhara, Rvoji
    Takeshita, Sunao
    Nimura, Yuji
    Ishida, Junji
    Fukamizu, Akiyoshi
    Ikeda, Kyoji
    JOURNAL OF BONE AND MINERAL RESEARCH, 2009, 24 (02) : 241 - 250
  • [24] BLOCKADE OF THE RENIN-ANGIOTENSIN SYSTEM
    NICHOLLS, MG
    CHARLES, CJ
    CROZIER, IG
    ESPINER, EA
    IKRAM, H
    RADEMAKER, MJ
    RICHARDS, AM
    YANDLE, TG
    JOURNAL OF HYPERTENSION, 1994, 12 : S95 - S103
  • [25] Combination renin-angiotensin system blockade with the renin inhibitor aliskiren in hypertension
    Doulton, Timothy W. R.
    MacGregor, Graham A.
    JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2009, 10 (04) : 185 - 189
  • [26] The renin-angiotensin system as a mediator of renal injury in hypertension
    Gharavi, A
    Klotman, P
    MOUNT SINAI JOURNAL OF MEDICINE, 1998, 65 (02): : 118 - 124
  • [27] Comparative effectiveness of renin-angiotensin system inhibitors in hypertension
    White, C. Michael
    JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH, 2012, 1 (02) : 125 - 127
  • [28] Gene polymorphisms of the renin-angiotensin system in essential hypertension
    Liu, Y
    Qiu, CC
    Zhou, WY
    Zheng, Y
    Hou, SQ
    Cao, J
    CHINESE MEDICAL JOURNAL, 1999, 112 (02) : 115 - 120
  • [29] The intrarenal renin-angiotensin system in hypertension: insights from mathematical modelling
    Delaney Smith
    Anita Layton
    Journal of Mathematical Biology, 2023, 86
  • [30] Molecular remodeling of the renin-angiotensin system after kidney transplantation
    Antlanger, Marlies
    Domenig, Oliver
    Kovarik, Johannes J.
    Kaltenecker, Christopher C.
    Kopecky, Chantal
    Poglitsch, Marko
    Saeemann, Marcus D.
    JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2017, 18 (02)
12345