MODULATION OF B2 CONTAINING SMALL RNAS DURING INDUCED-DIFFERENTIATION OF MURINE ERYTHROLEUKEMIA-CELLS

被引：4

作者：

KHOCHBIN, S

GRUNWALD, D

BERGERET, E

LAWRENCE, JJ

机构：

[1] Laboratoire de Biologie Moléculaire, Cycle Cellulaire Unité INSERM 309 Département de Biologie Moléculaire, Structurale Centre d'Etudes Nucléaires de Grenoble

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 175卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)81204-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We identified a B2 repetitive element approximately 1.9kb down stream from mouse p53 coding gene. This element was then used as a probe to investigate the expression of B2 containing RNA during the induced differentiation of murine erythroleukemia (MEL) cells. This probe revealed two nuclear and one cytoplasmic RNA species. Nuclear small RNAs had a biphasic variation: a decrease followed by a reaccumulation. The cytoplasmic species was essentially non polysomal, and disappeared after the induced differentiation. The presented results suggest that the regulation of these RNAs is associated to cell proliferation and differentiation respectively. © 1991 Academic Press, Inc.

引用

页码：91 / 97

页数：7

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