Future of bioartificial liver support

被引：22
作者：
Chamuleau, Robert A. F. M. [1 ]
机构：
[1] Univ Amsterdam, Dept Hepatol, Acad Med Ctr, S Bldg,Floor 1,Room 166,Meibergdreef 69-71, NL-1105 BK Amsterdam, Netherlands
来源：
WORLD JOURNAL OF GASTROINTESTINAL SURGERY | 2009年 / 1卷 / 01期
关键词：
Acute liver failure; Bioartificial liver; Liver transplantation; Cell transplantation; Tissue engineering; Xenotransplantation;
D O I：
10.4240/wjgs.v1.i1.21
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Many different artificial liver support systems (biological and non-biological) have been developed, tested pre-clinically and some have been applied in clinical trials. Based on theoretical considerations a biological artificial liver (BAL) should be preferred above the non-biological ones. However, clinical application of the BAL is still experimental. Here we try to analyze which hurdles have to be taken before the BAL will become standard equipment in the intensive care unit for patients with acute liver failure or acute deterioration of chronic liver disease. (C) 2009 Baishideng. All rights reserved.
引用
收藏
页码：21 / 25
页数：5
相关论文
共 51 条
[41]   Extracorporeal liver support based on primary human liver cells and albumin dialysis - treatment of a patient with primary graft non-function [J].
Sauer, IM ;
Zeilinger, K ;
Pless, G ;
Kardassis, D ;
Theruvath, T ;
Pascher, A ;
Goetz, M ;
Neuhaus, P ;
Gerlach, JC .
JOURNAL OF HEPATOLOGY, 2003, 39 (04) :649-653
[42]   What Clinical Alternatives to Whole Liver Transplantation? Current Status of Artificial Devices and Hepatocyte Transplantation [J].
Sgroi, Antonino ;
Serre-Beinier, Veronique ;
Morel, Philippe ;
Buehler, Leo .
TRANSPLANTATION, 2009, 87 (04) :457-466
[43]   Preclinical trial of a bioartificial liver support system in a porcine fulminant hepatic failure model [J].
Sheil, AGR ;
Sun, J ;
Mears, DC ;
Waring, M ;
Woodman, K ;
Johnston, B ;
Horvat, M ;
Watson, KJ ;
Koutalistras, N ;
Wang, LS .
AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY, 1996, 66 (08) :547-552
[44]   Assessment of the AMC-bioartificial liver in the anhepatic pig [J].
Sosef, MN ;
Abrahamse, LSL ;
van de Kerkhove, MP ;
Hartman, R ;
Chamuleau, RAFM ;
van Gulik, TM .
TRANSPLANTATION, 2002, 73 (02) :204-209
[45]   Acute liver failure: liver support therapies [J].
Stadbauer, Vanessa ;
Jalan, Rajiv .
CURRENT OPINION IN CRITICAL CARE, 2007, 13 (02) :215-221
[46]   A bioartificial liver - State of the art [J].
Strain, AJ ;
Neuberger, JM .
SCIENCE, 2002, 295 (5557) :1005-+
[47]   Follow-up by one- and two-dimensional NMR of plasma from pigs with ischemia-induced acute liver failure treated with a bioartificial liver [J].
Tréhout, D ;
Desille, M ;
Doan, BT ;
Mahler, S ;
Frémond, B ;
Mallédant, Y ;
Campion, JP ;
Desbois, J ;
Beloeil, JC ;
Certaines, J ;
Clément, B .
NMR IN BIOMEDICINE, 2002, 15 (06) :393-403
[48]   Clinical application of bioartificial liver support systems [J].
van de Kerkhove, MP ;
Hoekstra, R ;
Chamuleau, RAFM ;
van Gulik, TM .
ANNALS OF SURGERY, 2004, 240 (02) :216-230
[49]   Detection of PERV by polymerase chain reaction and its safety in bioartificial liver support system [J].
Wang, Hai-Hui ;
Wang, Ying-Jie ;
Liu, Hong-Ling ;
Liu, Jun ;
Huang, Yan-Ping ;
Guo, Hai-Tao ;
Wang, Yu-Ming .
WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (08) :1287-1291
[50]   Liver support systems: Promise and reality [J].
Wigg, AJ ;
Padbury, RT .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2005, 20 (12) :1807-1816
123456