Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease

被引：3
作者：
Oberdoerffer, Philipp [1 ]
机构：
[1] Natl Canc Inst, NIH, Lab Receptor Biol & Gene Express, Bethesda, MD USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2015年 / 2卷 / 01期
关键词：
DNA repair; chromatin; macroH2A1; senescence; replication stress;
D O I：
10.4161/23723548.2014.970952
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DNA damage is widely recognized for its potential to impair epigenetic integrity. Epigenetic defects are closely associated with a variety of diseases. We have recently uncovered DNA double-strand break-induced chromatin condensation as a critical modulator of repair outcome. Here, we discuss the possible implications for cell functions beyond repair.
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页数：3
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