Taq 1B polymorphism of cholesteryl ester transfer protein (CETP) in Egyptian patients with metabolic syndrome

被引：9

作者：

Elsammak, Mohamed Y. ^{[1
]}

Al-Sharkaweey, Rania M. ^{[1
]}

Fahmy, Mohamed ^{[2
]}

Reda, Ahmed A. ^{[2
]}

Farid, Walla ^{[2
]}

Emara, Ahmed ^{[2
]}

Hassan, Hesham ^{[2
]}

Kandil, Mona H. ^{[1
]}

机构：

[1] Alexandria Univ, Med Res Inst Teaching Hosp, Dept Chem Pathol, Alexandria, Egypt

[2] Menophiya Univ, Cardiol Dept, Shebeen Al Koum, Menophia, Egypt

来源：

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS | 2011年 / 5卷 / 02期

关键词：

CETP; HDL-C; Metabolic syndrome;

D O I：

10.1016/j.dsx.2010.12.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: We aimed at evaluation of the possible association of cholesteryl ester transfer protein (CETP) Taq1B polymorphism with the components of metabolic syndrome in a cohort of Egyptian patients compared to their healthy counterparts. Patients and methods: Blood samples were collected for lipid profile, fasting glucose, insulin and routine biochemical tests. The Taq1B genotypes of CETP were determined using RFLP-PCR technique. Results: The patients group showed a significantly higher B1B1 genotype and lower B2B2 genotype compared to the controls group. Serum HDL-C level was significantly higher in all subjects with the B2B2 genotype compared to those with B1B1 genotype. In the patients group, age positively correlated with cholesterol level, triglycerides, BMI and waist circumference. Conclusion: Egyptian patients affected with metabolic syndrome have a higher prevalence of B1B1 genotype that is associated with lower serum HDL-C levels. (C) 2010 Diabetes India. Published by Elsevier Ltd. All rights reserved.

引用

页码：61 / 65

页数：5

共 25 条

[1] A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study [J].

Asselbergs, Folkert W. ;

Moore, Jason H. ;

van den Berg, Maarten P. ;

Rimm, Eric B. ;

de Boer, Rudolf A. ;

Dullaart, Robin P. ;

Navis, Gerjan ;

van Gilst, Wiek H. .

BMC MEDICAL GENETICS, 2006, 7

[2] Atheroprotective effects of high-density lipoproteins [J].

Assmann, G ;

Nofer, JR .

ANNUAL REVIEW OF MEDICINE, 2003, 54 :321-341

[3]

Ausubel F, 1987, CURRENT PROTOCOLS MO

[4] Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women - The prospective EPIC (European Prospective Investigation into Cancer and Nutrition) - Norfolk population study [J].

Boekholdt, SM ;

Kuivenhoven, JA ;

Wareham, NJ ;

Peters, RJG ;

Jukema, JW ;

Luben, R ;

Bingham, SA ;

Day, NE ;

Kastelein, JJP ;

Khaw, KT .

CIRCULATION, 2004, 110 (11) :1418-1423

[5] CETP gene variation: relation to lipid parameters and cardiovascular risk [J].

Boekholdt, SM ;

Kuivenhoven, JA ;

Hovingh, GK ;

Jukema, JW ;

Kastelein, JJP ;

van Tol, A .

CURRENT OPINION IN LIPIDOLOGY, 2004, 15 (04) :393-398

[6] The effect of cholesteryl ester transfer protein-629C→A promoter polymorphism on high-density lipoprotein cholesterol is dependent on serum triglycerides [J].

Borggreve, SE ;

Hillege, HL ;

Wolffenbuttel, BHR ;

de Jong, PE ;

Bakker, SJL ;

van der Steege, G ;

van Tol, A ;

Dullaart, RPF .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (07) :4198-4204

[7]

Burtis C. A., 1996, TIETZ FUNDAMENTAL CL

[8]

Du J, 2010, J NUTR BIOCH

[9] Common variation in the CETP gene and the implications for cardiovascular disease and its treatment:: an updated analysis [J].

Dullaart, Robin P. F. ;

Sluiter, Wim J. .

PHARMACOGENOMICS, 2008, 9 (06) :747-763

[10] The metabolic syndrome [J].

Eckel, Robert H. ;

Alberti, K. G. M. M. ;

Grundy, Scott M. ;

Zimmet, Paul Z. .

LANCET, 2010, 375 (9710) :181-183

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