Ectopic Germinal Centers and IgG4-Producing Plasmacytes Observed in Synovia of HLA-B27+ Ankylosing Spondylitis Patients with Advanced Hip Involvement

被引：6

作者：

Feng, Xiugao ^{[1
]}

Xu, Xiangjin ^{[1
]}

Wang, Yue ^{[1
]}

Zheng, Zhiyong ^{[2
]}

Lin, Guiying ^{[1
]}

机构：

[1] PLA, Fuzhou Gen Hosp Nanjing Command, Dept Rheumatol, Fuzhou 350025, Fujian, Peoples R China

[2] PLA, Fuzhou Gen Hosp Nanjing Command, Dept Pathol, Fuzhou 350025, Fujian, Peoples R China

来源：

INTERNATIONAL JOURNAL OF RHEUMATOLOGY | 2015年 / 2015卷

关键词：

D O I：

10.1155/2015/316421

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction. Ectopic lymphoid neogenesis and the presence of IgG4-positive plasmacytes have been confirmed in chronic inflammatory sclerosing diseases. This study aims to investigate hip synovial tissues of ankylosing spondylitis (AS) patients for IgG4-positive plasma cells and ectopic lymphoid tissues with germinal centers (GCs). Methods. Synovial samples were collected from7 AS patients who received total hip replacement and were evaluated using immunohistochemistry for the presence of CD20+ B-cells, CD3+ T-cells, CD21+ follicular dendritic cells (FDC), and CD38+ plasma cells. Furthermore, immunoglobulin G (IgG and IgG4), IgA, IgM, and complement components C3d and C4d in synovia were evaluated. Both synovial CD21+ FDCs and IgG4-producing plasmacytes were analyzed. Results. All seven patients had severe fibrosis. Massive infiltrations of lymphocytes were found in 5 out of 7 patients' synovia. Ectopic lymphoid tissues with CD21+ FDC networks and IgG4-positive plasma cells were observed coincidentally in two patients' synovia. Conclusion. The pathophysiological mechanism of AS patients' hip damage might be related to the coincidental presence of ectopic lymphoid tissue with FDCs network and IgG4-positive plasma cells identified here for the first time in AS patients' inflamed synovial tissue.

引用

页数：6

共 16 条

[1] Lymphoid neogenesis in chronic inflammatory diseases [J].

Aloisi, F ;

Pujol-Borrell, R .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (03) :205-217

[2]

Appel H, 2009, CLIN EXP RHEUMATOL, V27, pS15

[3] 2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis [J].

Braun, J. ;

van den Berg, R. ;

Baraliakos, X. ;

Boehm, H. ;

Burgos-Vargas, R. ;

Collantes-Estevez, E. ;

Dagfinrud, H. ;

Dijkmans, B. ;

Dougados, M. ;

Emery, P. ;

Geher, P. ;

Hammoudeh, M. ;

Inman, R. D. ;

Jongkees, M. ;

Khan, M. A. ;

Kiltz, U. ;

Kvien, T. K. ;

Leirisalo-Repo, M. ;

Maksymowych, W. P. ;

Olivieri, I. ;

Pavelka, K. ;

Sieper, J. ;

Stanislawska-Biernat, E. ;

Wendling, D. ;

Ozgocmen, S. ;

van Drogen, C. ;

van Royen, B. J. ;

van der Heijde, D. .

ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (06) :896-904

[4] IgG4-related Sclerosing Disease A Critical Appraisal of an Evolving Clinicopathologic Entity [J].

Cheuk, Wah ;

Chan, John K. C. .

ADVANCES IN ANATOMIC PATHOLOGY, 2010, 17 (05) :303-332

[5] Extranodal Lymphoid Microstructures in Inflamed Muscle and Disease Severity of New-Onset Juvenile Dermatomyositis [J].

de Padilla, Consuelo M. Lopez ;

Vallejo, Abbe N. ;

Lacomis, David ;

McNallan, Kelly ;

Reed, Ann M. .

ARTHRITIS AND RHEUMATISM, 2009, 60 (04) :1160-1172

[6] Recent Chlamydia pneumoniae infection is highly associated with active ankylosing spondylitis in a Chinese cohort [J].

Feng, X. G. ;

Xu, X. J. ;

Ye, S. ;

Lin, Y. Y. ;

Chen, P. ;

Zhang, X. J. ;

Lin, G. Y. ;

Lin, X. Q. .

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2011, 40 (04) :289-291

[7] Lymphoid neogenesis in juvenile idiopathic arthritis correlates with ANA positivity and plasma cells infiltration [J].

Gregorio, A. ;

Gambini, C. ;

Gerloni, V. ;

Parafioriti, A. ;

Sormani, M. P. ;

Gregorio, S. ;

De Marco, G. ;

Rossi, F. ;

Martini, A. ;

Gattorno, M. .

RHEUMATOLOGY, 2007, 46 (02) :308-313

[8] Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium [J].

Humby, Frances ;

Bombardieri, Michele ;

Manzo, Antonio ;

Kelly, Stephen ;

Blades, Mark C. ;

Kirkham, Bruce ;

Spencer, Jo ;

Pitzalis, Costantino .

PLOS MEDICINE, 2009, 6 (01) :59-75

[9] Autoimmune pancreatitis: proposal of IgG4-related sclerosing disease [J].

Kamisawa, Terumi ;

Okamoto, Atsutake .

JOURNAL OF GASTROENTEROLOGY, 2006, 41 (07) :613-625

[10] HISTOPATHOLOGY OF THE SYNOVIAL-MEMBRANE OF PERIPHERAL JOINTS IN ANKYLOSING-SPONDYLITIS [J].

REVELL, PA ;

MAYSTON, V .

ANNALS OF THE RHEUMATIC DISEASES, 1982, 41 (06) :579-586

← 1 2 →