EFFECTS OF 1 YEAR OF GROWTH-HORMONE THERAPY ON SERUM-LIPOPROTEIN LEVELS IN GROWTH HORMONE-DEFICIENT ADULTS - INFLUENCE OF GENDER AND APO(A) AND APOE PHENOTYPES

被引:99
作者
JOHANNSSON, G
OSCARSSON, J
ROSEN, T
WIKLUND, O
OLSSON, G
WILHELMSEN, L
BENGTSSON, BA
机构
[1] SAHLGRENS UNIV HOSP, WALLENBERG LAB, GOTHENBURG, SWEDEN
[2] OSTRA UNIV HOSP, DEPT MED, GOTHENBURG, SWEDEN
关键词
GROWTH HORMONE; LIPOPROTEINS; APO(A) PHENOTYPE; APOE PHENOTYPE; GENDER;
D O I
10.1161/01.ATV.15.12.2142
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We investigated the influence of gender and apoE and apo(a) phenotypes as well as the effect of the metabolic effects of growth hormone (GH) on the effect of GH therapy on serum lipoprotein concentrations in GH-deficient (GHD) adults. Forty-four consecutive patients, 30 men and 14 women aged 46.5 (range, 19 to 76) years with GHD due mainly to pituitary tumors, were treated with recombinant human GH for 12 months. Serum concentrations of lipoproteins, insulin, thyroxine, and insulin-like growth factor-I were determined, body composition was assessed by bioelectrical impedance, and apo(a) and apoE phenotypes were analyzed. Lipoprotein(a) [Lp(a)] concentrations in the GHD subjects were compared with a gender- and apo(a) phenotype-matched control group. After 12 months of GH treatment, the total cholesterol, LDL cholesterol, and apoB concentrations decreased, the HDL cholesterol and apoE concentrations increased, and the apoA-I and triglyceride concentrations were unchanged. Before treatment, the Lp(a) concentration was similar to that in the control group. However: after 12 months of treatment, the Lp(a) concentration had increased by 44% and 101% above baseline and the control group, respectively. Men and women responded differently to GH, with a more marked increase in Lp(a) concentration and fat-free mass and a more pronounced decrease in body-fat mass in men. Apo(a) phenotypes had no major influence on the effect of GPI therapy. The only significant difference between apoE phenotypes was a higher baseline Lp(a) concentration among apoE4 heterozygotes. Changes in body composition, insulin, insulin-like growth factor-I, and thyroxine concentrations explained at most 27% of the changes that occurred in serum lipoprotein levels during GH treatment. The effects of GH therapy on serum lipoprotein levels and body composition in GHD adults were dependent in part on gender or current sex hormone therapy. However, no major influence by apo(a) or apoE phenotype or changes in metabolic variables were detected on the effects of GH therapy on serum lipoprotein levels.
引用
收藏
页码:2142 / 2150
页数:9
相关论文
共 57 条
[1]  
Angelin Bo, 1994, Current Opinion in Lipidology, V5, P160, DOI 10.1097/00041433-199405030-00002
[2]  
[Anonymous], ENDOCRINOL METAB
[3]   EPIDEMIOLOGY OF TRIGLYCERIDES, SMALL DENSE LOW-DENSITY-LIPOPROTEIN, AND LIPOPROTEIN(A) AS RISK-FACTORS FOR CORONARY HEART-DISEASE [J].
AUSTIN, MA ;
HOKANSON, JE .
MEDICAL CLINICS OF NORTH AMERICA, 1994, 78 (01) :99-115
[4]   REGRESSION OF ATHEROSCLEROTIC LESIONS BY HIGH-DENSITY-LIPOPROTEIN PLASMA FRACTION IN THE CHOLESTEROL-FED RABBIT [J].
BADIMON, JJ ;
BADIMON, L ;
FUSTER, V .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (04) :1234-1241
[5]   TREATMENT OF ADULTS WITH GROWTH-HORMONE (GH) DEFICIENCY WITH RECOMBINANT HUMAN GH [J].
BENGTSSON, BA ;
EDEN, S ;
LONN, L ;
KVIST, H ;
STOKLAND, A ;
LINDSTEDT, G ;
BOSAEUS, I ;
TOLLI, J ;
SJOSTROM, L ;
ISAKSSON, OGP .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 76 (02) :309-317
[6]  
BENGTSSON BA, 1993, ACTA ENDOCRINOL-COP, V128, P2
[7]   THE EFFECT OF GROWTH-HORMONE ADMINISTRATION IN GROWTH-HORMONE DEFICIENT ADULTS ON BONE, PROTEIN, CARBOHYDRATE AND LIPID HOMEOSTASIS, AS WELL AS ON BODY-COMPOSITION [J].
BINNERTS, A ;
SWART, GR ;
WILSON, JHP ;
HOOGERBRUGGE, N ;
POLS, HAP ;
BIRKENHAGER, JC ;
LAMBERTS, SWJ .
CLINICAL ENDOCRINOLOGY, 1992, 37 (01) :79-87
[8]  
BOUTHILLIER D, 1983, J LIPID RES, V24, P1060
[9]  
BRUMMER RJM, 1993, ACTA ENDOCRINOL-COP, V128, P30
[10]   GROWTH-HORMONE TREATMENT IMPROVES SERUM-LIPIDS AND LIPOPROTEINS IN ADULTS WITH GROWTH-HORMONE DEFICIENCY [J].
CUNEO, RC ;
SALOMON, F ;
WATTS, GF ;
HESP, R ;
SONKSEN, PH .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1993, 42 (12) :1519-1523