REDUNDANT DOMAINS CONTRIBUTE TO THE TRANSCRIPTIONAL ACTIVITY OF THE THYROID-TRANSCRIPTION-FACTOR-1

被引:105
作者
DEFELICE, M
DAMANTE, G
ZANNINI, M
FRANCISLANG, H
DILAURO, R
机构
[1] STAZ ZOOL ANTON DOHRN, FAC MED, IST PLURIDISCIPLINARE PATOL GEN, I-80121 NAPLES, ITALY
[2] UNIV MESSINA, I-98100 MESSINA, ITALY
[3] DIPARTIMENTO SCI & TECNOL BIOMED, I-33100 UDINE, ITALY
关键词
D O I
10.1074/jbc.270.44.26649
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing protein implicated in the activation of thyroid-specific gene expression. Here we report that TTF-1 is capable of activating transcription from thyroglobulin and, to a lesser extent, thyroperoxidase gene promoters in nonthyroid cells. Full transcriptional activation of the thyroglobulin promoter by TTF-1 requires the presence of at least two TTF-1 binding sites. TTF-1 activates transcription via two functionally redundant transcriptional activation domains that as suggested by competition experiments, could use a common intermediary factor.
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收藏
页码:26649 / 26656
页数:8
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