NATIVE-LIKE AND STRUCTURALLY CHARACTERIZED DESIGNED ALPHA-HELICAL BUNDLES

被引：107
作者：
BETZ, SF
BRYSON, JW
DEGRADO, WF
机构：
[1] The DuPont Merck Pharmaceutical Company, Wilmington
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 04期
关键词：
D O I：
10.1016/0959-440X(95)80029-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A number of coiled coils and alpha-helical bundles have recently been designed, and many have now been structurally characterized by X-ray crystallography. Others have not been as well characterized structurally but exhibit native-like properties in aqueous solution. Both areas of investigation have contributed greatly to our understanding of the nature of specificity in this class of molecules.
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页码：457 / 463
页数：7
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