THE HUMAN PHENOLSULFOTRANSFERASE POLYMORPHISM IS DETERMINED BY THE LEVEL OF EXPRESSION OF THE ENZYME PROTEIN

被引：55
作者：
JONES, AL
ROBERTS, RC
COUGHTRIE, MWH
机构：
[1] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT BIOCHEM MED,DUNDEE DD1 9SY,SCOTLAND
[2] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT MED,DUNDEE DD1 9SY,SCOTLAND
来源：
BIOCHEMICAL JOURNAL | 1993年 / 296卷
关键词：
D O I：
10.1042/bj2960287
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have examined the expression of platelet phenolsulphotransferase (PST) in 60 individuals. Using an antibody which recognizes both forms of PST present in man (P-PST and M-PST), we determined that the polymorphism of platelet P-PST activity is determined by the level of expression of the enzyme protein. The implications for susceptibility to adverse drug reactions and chemical carcinogenesis are discussed.
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页码：287 / 290
页数：4
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