THE HUMAN PHENOLSULFOTRANSFERASE POLYMORPHISM IS DETERMINED BY THE LEVEL OF EXPRESSION OF THE ENZYME PROTEIN

被引：55
作者：
JONES, AL
ROBERTS, RC
COUGHTRIE, MWH
机构：
[1] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT BIOCHEM MED,DUNDEE DD1 9SY,SCOTLAND
[2] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT MED,DUNDEE DD1 9SY,SCOTLAND
来源：
BIOCHEMICAL JOURNAL | 1993年 / 296卷
关键词：
D O I：
10.1042/bj2960287
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have examined the expression of platelet phenolsulphotransferase (PST) in 60 individuals. Using an antibody which recognizes both forms of PST present in man (P-PST and M-PST), we determined that the polymorphism of platelet P-PST activity is determined by the level of expression of the enzyme protein. The implications for susceptibility to adverse drug reactions and chemical carcinogenesis are discussed.
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页码：287 / 290
页数：4
相关论文
共 31 条
[1]   HUMAN-PLATELET PHENOL SULFOTRANSFERASE - ASSAY PROCEDURE, SUBSTRATE AND TISSUE CORRELATIONS [J].
ANDERSON, RJ ;
WEINSHILBOUM, RM ;
PHILLIPS, SF ;
BROUGHTON, DD .
CLINICA CHIMICA ACTA, 1981, 110 (2-3) :157-167
[2]  
Bonham Carter S M, 1983, Br J Clin Pharmacol, V15, P323
[3]   PURIFICATION AND IMMUNOCHEMICAL CHARACTERIZATION OF A MALE-SPECIFIC RAT-LIVER ESTROGEN SULFOTRANSFERASE [J].
BORTHWICK, EB ;
BURCHELL, A ;
COUGHTRIE, MWH .
BIOCHEMICAL JOURNAL, 1993, 289 :719-725
[4]   HUMAN-PLATELET PHENOL SULFOTRANSFERASE - PARTIAL-PURIFICATION AND DETECTION OF 2 FORMS OF THE ENZYME [J].
BUTLER, PR ;
ANDERSON, RJ ;
VENTON, DL .
JOURNAL OF NEUROCHEMISTRY, 1983, 41 (03) :630-639
[5]   SULFATE AND METHYLDOPA METABOLISM - METABOLITE PATTERNS AND PLATELET PHENOL SULFOTRANSFERASE ACTIVITY [J].
CAMPBELL, NRC ;
SUNDARAM, RS ;
WERNESS, PG ;
VANLOON, J ;
WEINSHILBOUM, RM .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1985, 37 (03) :308-315
[6]   HUMAN-LIVER PHENOL SULFOTRANSFERASE - ASSAY CONDITIONS, BIOCHEMICAL-PROPERTIES AND PARTIAL-PURIFICATION OF ISOZYMES OF THE THERMOSTABLE FORM [J].
CAMPBELL, NRC ;
VANLOON, JA ;
WEINSHILBOUM, RM .
BIOCHEMICAL PHARMACOLOGY, 1987, 36 (09) :1435-1446
[7]  
CARTER SMB, 1981, CLIN CHIM ACTA, V117, P333
[8]  
COUGHTRIE MWH, 1988, MOL PHARMACOL, V34, P729
[9]   MOLECULAR ENZYMOLOGY OF HUMAN LIVER CYTOSOLIC SULFOTRANSFERASES [J].
FALANY, CN .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (07) :255-259
[10]  
FALANY CN, 1993, HUMAN DRUG METABOLIS, P102
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