THE ETIOPATHOGENETIC IMPORTANCE OF VITAMIN-D3 IN PSORIATIC-ARTHRITIS

1.25 (OH)2 D3 is the most effective natural metabolite of vitamin D. By binding to a specific receptor (VDR) it develops genomic as well as non genomic effects which exceed the effects on calcium regulation. Exercising an influence on immunological phenomena and on the behavior of cellular differentiation and proliferation, the different manifestations of psoriatic osteorthropathy (skin lesions, chronic synovialitis, increased bone remodeling) may be due to a common pathogenetic process of a disturbed vitamin D metabolism. However, the supposed fault has not yet been defined and this concept is still hypothetical. Moreover, it is probable that it represents a partial aspect only in the quite unclear pathogenesis of the disease.