[1,2-BIS(2-HYDROXYPHENYL)ETHYLENEDIAMINE]DICHLOROPLATINUM(II), A NEW COMPOUND FOR THE THERAPY OF OVARIAN-CANCER .2. SYNTHESIS AND PRELIMINARY TESTING OF THE ENANTIOMERIC COMPLEXES

被引：11

作者：

BERNHARDT, G

GUST, R

REILE, H

VOMORDE, HD

MULLER, R

KELLER, C

SPRUSS, T

SCHONENBERGER, H

BURGEMEISTER, T

MANNSCHRECK, A

RANGE, KJ

KLEMENT, U

机构：

[1] UNIV REGENSBURG,INST PHARM,LEHRSTUHL PHARMAZEUT CHEM 2,SONDERFORSCHUNGSBEREICH 234,W-8400 REGENSBURG,GERMANY

[2] UNIV REGENSBURG,INST ORGAN CHEM,SONDERFORSCHUNGSBEREICH 234,W-8400 REGENSBURG,GERMANY

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1992年 / 118卷 / 03期

关键词：

(R,R)-[1,2-BIS(2-HYDROXYPHENYL)-ETHYLENEDIAMINE]DICHLOROPLATINUM(II); (S,S)-[1,2-BIS(2-HYDROXYPHENYL)-ETHYLENEDIAMINE]DICHLOROPLATINUM(II); NIH-OVCAR-3 OVARIAN CANCER CELL LINE; PRELIMINARY TESTING; SYNTHESIS;

D O I：

10.1007/BF01410135

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The enantiomeric [1,2-bis(2-hydroxyphenyl)ethylenediamine] dichloroplatinum(II) complexes were synthesized and their configuration assessed. A preliminary test in the cisplatin-resistant human NIH:OVCAR-3 ovarian cancer cell line, which was previously characterized by its sensitivity against several therapeutically used drugs, showed that both enantiomers produce cytocidal effects in a concentration of 2.5-mu-M. A difference between the enantiomers became evident from the faster onset of cytocidal activity of the S,S-configurated compound.

引用

页码：201 / 208

页数：8

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