CONTROL OF HUMAN-IMMUNODEFICIENCY-VIRUS REPLICATION BY THE TAT, REV, NEF AND PROTEASE GENES

被引:28
作者
KARN, J
机构
[1] MRC Laboratory of Molecular Biology, Cambridge
关键词
D O I
10.1016/0952-7915(91)90016-T
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immediately after infection, human immunodeficiency virus directs the synthesis of three regulatory proteins tat, rev and nef that together allow the synthesis of the structural proteins of the virus after a delay of several hours. Viral mRNA production is controlled by the tat gene, which appears to stimulate elongation by RNA polymerase II, and the rev gene, which allows the accumulation of unspliced or partially spliced mRNAs in the cytoplasm. The nef gene is dispensable for virus growth but may limit virus spread by downregulating the levels of cellular surface proteins such as the CD4 receptor. Virus maturation also depends critically on the protease gene which allows the orderly rearrangement of the viral core structures in newly budded virions as well as the vpu and vif genes which allow efficient production of mature envelope glycoprotein.
引用
收藏
页码:526 / 536
页数:11
相关论文
共 50 条
  • [1] CHARACTERIZATION AND EXPRESSION OF NOVEL SINGLY SPLICED RNA SPECIES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1
    ARRIGO, SJ
    WEITSMAN, S
    ZACK, JA
    CHEN, ISY
    [J]. JOURNAL OF VIROLOGY, 1990, 64 (09) : 4585 - 4588
  • [2] HIV ENHANCER ACTIVITY PERPETUATED BY NF-KAPPA-B INDUCTION ON INFECTION OF MONOCYTES
    BACHELERIE, F
    ALCAMI, J
    ARENZANASEISDEDOS, F
    VIRELIZIER, JL
    [J]. NATURE, 1991, 350 (6320) : 709 - 712
  • [3] CELLULAR FACTORS REGULATE TRANSACTIVATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1
    BARRY, PA
    PRATTLOWE, E
    UNGER, RE
    LUCIW, PA
    [J]. JOURNAL OF VIROLOGY, 1991, 65 (03) : 1392 - 1399
  • [4] TAT TRANS-ACTIVATES THE HUMAN IMMUNODEFICIENCY VIRUS THROUGH A NASCENT RNA TARGET
    BERKHOUT, B
    SILVERMAN, RH
    JEANG, KT
    [J]. CELL, 1989, 59 (02) : 273 - 282
  • [5] TAR-INDEPENDENT ACTIVATION OF THE HIV-1-LTR - EVIDENCE THAT TAT REQUIRES SPECIFIC REGIONS OF THE PROMOTER
    BERKHOUT, B
    GATIGNOL, A
    RABSON, AB
    JEANG, KT
    [J]. CELL, 1990, 62 (04) : 757 - 767
  • [6] A NUCLEAR TRANSLATIONAL BLOCK IMPOSED BY THE HIV-1 U3 REGION IS RELIEVED BY THE TAT-TAR INTERACTION
    BRADDOCK, M
    THORBURN, AM
    CHAMBERS, A
    ELLIOTT, GD
    ANDERSON, GJ
    KINGSMAN, AJ
    KINGSMAN, SM
    [J]. CELL, 1990, 62 (06) : 1123 - 1133
  • [7] REGULATION BY HIV REV DEPENDS UPON RECOGNITION OF SPLICE SITES
    CHANG, DD
    SHARP, PA
    [J]. CELL, 1989, 59 (05) : 789 - 795
  • [8] DIFFERENTIAL-EFFECTS OF NEF ON HIV REPLICATION - IMPLICATIONS FOR VIRAL PATHOGENESIS IN THE HOST
    CHENGMAYER, C
    IANNELLO, P
    SHAW, K
    LUCIW, PA
    LEVY, JA
    [J]. SCIENCE, 1989, 246 (4937) : 1629 - 1632
  • [9] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TAT DOES NOT TRANSACTIVATE MATURE TRANS-ACTING RESPONSIVE REGION RNA SPECIES IN THE NUCLEUS OR CYTOPLASM OF PRIMATE CELLS
    CHIN, DJ
    SELBY, MJ
    PETERLIN, BM
    [J]. JOURNAL OF VIROLOGY, 1991, 65 (04) : 1758 - 1764
  • [10] SEQUENCE-SPECIFIC INTERACTION OF TAT PROTEIN AND TAT PEPTIDES WITH THE TRANSACTIVATION-RESPONSIVE SEQUENCE ELEMENT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INVITRO
    CORDINGLEY, MG
    LAFEMINA, RL
    CALLAHAN, PL
    CONDRA, JH
    SARDANA, VV
    GRAHAM, DJ
    NGUYEN, TM
    LEGROW, K
    GOTLIB, L
    SCHLABACH, AJ
    COLONNO, RJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (22) : 8985 - 8989