GAS-LIQUID-CHROMATOGRAPHIC DETERMINATION OF NIKETHAMIDE IN INJECTABLE PREPARATIONS

被引：0

作者：

NEWTON, JM ^{[1
]}

机构：

[1] FDA, 50 FULTON ST, SAN FRANCISCO, CA 94102 USA

来源：

JOURNAL OF THE ASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS | 1976年 / 59卷 / 01期

关键词：

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A GLC method, using a 4% XE-60 on 80-100 mesh Gas-Chrom Q column, a flame ionization detector and anthracene as the internal standard, was developed for the direct determination of nikethamide which may be of value in detecting the drug concentration in biological fluids. Eight collaborators analyzed 4 samples, using methanol as the solvent; the coefficients of variation obtained ranged from 1.19-3.20%. In a limited study with acetone as the solvent, the coefficients of variation ranged from 0.59-1.96%. The GLC method with acetone as a solvent was adopted as official 1st action.

引用

页码：93 / 97

页数：5