Bisoprolol and metformin in patients with arterial hypertension and metabolic syndrome

被引：0

作者：

Nevzorova, V. A. ^{[1
]}

Zakcharchuk, N. V. ^{[1
]}

Nastradin, O. V. ^{[1
]}

Pomogalova, O. G. ^{[1
]}

机构：

[1] Vladivostok State Med Univ, Vladivostok, Russia

来源：

RATIONAL PHARMACOTHERAPY IN CARDIOLOGY | 2007年 / 3卷 / 05期

关键词：

bisoprolol; metformin; arterial hypertension; metabolic syndrome;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim. To compare efficacy of bisoprolol and bisoprolol+metformin combination in patients with arterial hypertension (AH) and metabolic syndrome (MS). Material and methods. 20 patients with AH and MS were involved in the study. They were randomized in 2 groups, 10 patients in each group. Patients of the 1st group received bisoprolol. Patients of the 2nd group received combination of bisoprolol and metformin. Blood pressure (BP), body mass index (BMI), carbohydrate metabolism, lipid profile, microalbuminuria (MAU) level was determined before, within and at the end of 24-week treatment. Results. Both treatments resulted in similar reduction in BP. Reduction of BMI and insulin plasma concentration was more significant in patients received combined therapy. Both treatments improved lipid profile and reduced MAU. Conclusion. Bisoprolol has positive effect on pathogenic mechanisms of AH and MS. Metformin additionally improves carbohydrate and lipid metabolism.

引用

页码：54 / 57

页数：4

共 9 条

[1] General characteristics of the insulin resistance syndrome - Prevalence and heritability [J].

Beck-Nielsen, H .

DRUGS, 1999, 58 (Suppl 1) :7-10

[2]

Fudjii S., 1998, J ATHEROSCLER THROMB, V28, P100

[3] The Metabolic Syndrome X [J].

Hansen, BC .

THE METABOLIC SYNDROME X: CONVERGENCE OF INSULIN RESISTANCE, GLUCOSE INTOLERANCE, HYPERTENSION, OBESITY, AND DYSLIPIDEMIAS-SEARCHING FOR THE UNDERLYING DEFECTS, 1999, 892 :1-24

[4] Cardiovascular morbidity and mortality associated with the metabolic syndrome [J].