APPARENT PROTON-CATALYZED MEERWEIN-PONNDORF-VERLEY TYPE REDUCTION OF 8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL-6H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE

被引:4
作者
RAMIG, K [1 ]
KUZEMKO, MA [1 ]
PARRISH, D [1 ]
CARPENTER, BK [1 ]
机构
[1] CORNELL UNIV,DEPT CHEM,BAKER LAB,ITHACA,NY 14853
关键词
D O I
10.1016/S0040-4039(00)60952-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
When treated with 2-propanol in the presence of HCl, reduction of the C4-N double bond in 8-chloro-6-(2-fluorophenyl)-1-methyl-6H-imidazo[1,5-a][1,4]benzodiazepine occurs. Data are presented which indicate 2-propanol is the reductant in a two-step mechanism.
引用
收藏
页码:6279 / 6282
页数:4
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