APPARENT PROTON-CATALYZED MEERWEIN-PONNDORF-VERLEY TYPE REDUCTION OF 8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL-6H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE

被引：4

作者：

RAMIG, K ^{[1
]}

KUZEMKO, MA ^{[1
]}

PARRISH, D ^{[1
]}

CARPENTER, BK ^{[1
]}

机构：

[1] CORNELL UNIV,DEPT CHEM,BAKER LAB,ITHACA,NY 14853

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(00)60952-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

When treated with 2-propanol in the presence of HCl, reduction of the C4-N double bond in 8-chloro-6-(2-fluorophenyl)-1-methyl-6H-imidazo[1,5-a][1,4]benzodiazepine occurs. Data are presented which indicate 2-propanol is the reductant in a two-step mechanism.

引用

页码：6279 / 6282

页数：4

共 6 条

[1] THE DEVELOPMENT AND USE OF QUANTUM-MECHANICAL MOLECULAR-MODELS .76. AM1 - A NEW GENERAL-PURPOSE QUANTUM-MECHANICAL MOLECULAR-MODEL [J].