LYMPHOCYTE-T-SYNOVIAL FIBROBLAST INTERACTIONS INDUCED BY MYCOBACTERIAL PROTEINS IN RHEUMATOID-ARTHRITIS

被引：16
作者：
HOLOSHITZ, J
KOSEK, J
SIBLEY, R
BROWN, DA
STROBER, S
机构：
[1] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,DIV IMMUNOL & RHEUMATOL,STANFORD,CA 94305
[2] STANFORD UNIV,MED CTR,SCH MED,DEPT PATHOL,STANFORD,CA 94305
来源：
ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 06期
关键词：
D O I：
10.1002/art.1780340608
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
An in vitro system was established in which single-cell suspensions of lymphocytes and synovial cells from the joints of patients with rheumatoid arthritis were cultured and produced an outgrowth of an organized inflammatory tissue with an extracellular matrix and capsule. The tissue outgrowth, which had histologic features of pannus, required the addition of mycobacterial antigen and interleukin-2 to the tissue culture medium and was dependent upon the presence of T lymphocytes and their interaction with synovial fibroblasts.
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页码：679 / 686
页数：8
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