DIVERSITY OF HUMAN GAMMA-GLOBIN GENE LOCI INCLUDING A QUADRUPLICATED ARRANGEMENT

被引：0
|
作者：
SHIMASAKI, S [1 ]
IUCHI, I [1 ]
机构：
[1] KAWASAKI MED SCH, DEPT BIOCHEM, 577 MATSUSHIMA, KURASHIKI, OKAYAMA 70101, JAPAN
来源：
BLOOD | 1986年 / 67卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A quadruplicated .gamma.-globin gene as a (5''-G.gamma.-.gamma.-.gamma.-A.gamma.-3'') was detected in an adult Chinese during a survey designed to detect G.gamma.- and A.gamma.-globin genes in Japanese. Five triplicated (-G.gamma.-.gamma.-A.gamma.-) and two single (-.gamma.-) haplotypes were also detected in 103 healthy adult Japanese. All of the unusual chromosomes appeared to reflect an unequal but homologous crossover between G.gamma.- and A.gamma.-globin genes. A new Bgl II polymorphic site located around the 3'' terminal region of the G.gamma.-globin gene was also discovered.
引用
收藏
页码：784 / 788
页数：5
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