UNEXPECTED GROWTH-STIMULATORY EFFECT OF SOMATOSTATIN ANALOG ON CULTURED HUMAN PANCREATIC CARCINOID CELLS

被引：22

作者：

ISHIZUKA, J

BEAUCHAMP, RD

EVERS, BM

TOWNSEND, CM

THOMPSON, JC

机构：

[1] Department of Surgery, The University of Texas Medical Branch, Galveston

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91663-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells. © 1992.

引用

页码：577 / 581

页数：5

共 15 条

[11]

SOUQUET JC, 1987, CANCER, V59, P1654, DOI 10.1002/1097-0142(19870501)59:9<1654::AID-CNCR2820590922>3.0.CO

[12]

2-C

[13] CONVENIENT ELIMINATION OF TRICHLOROACETIC-ACID PRIOR TO RADIOIMMUNOASSAY OF CYCLIC NUCLEOTIDES [J].

TIHON, C ;

GOREN, MB ;

SPITZ, E ;

RICKENBERG, HV .

ANALYTICAL BIOCHEMISTRY, 1977, 80 (02) :652-653

[14] TUMOR-REGRESSION OF AN ILEAL CARCINOID UNDER THE TREATMENT WITH THE SOMATOSTATIN ANALOG SMS-201-995 [J].

WIEDENMANN, B ;

RATH, U ;

RADSCH, R ;

BECKER, F ;

KOMMERELL, B .

KLINISCHE WOCHENSCHRIFT, 1988, 66 (02) :75-77

[15]

Williams G, 1987, Acta Endocrinol Suppl (Copenh), V286, P26

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