UNEXPECTED GROWTH-STIMULATORY EFFECT OF SOMATOSTATIN ANALOG ON CULTURED HUMAN PANCREATIC CARCINOID CELLS

被引：22
作者：
ISHIZUKA, J
BEAUCHAMP, RD
EVERS, BM
TOWNSEND, CM
THOMPSON, JC
机构：
[1] Department of Surgery, The University of Texas Medical Branch, Galveston
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 02期
关键词：
D O I：
10.1016/0006-291X(92)91663-B
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells. © 1992.
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页码：577 / 581
页数：5
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