TRANSPORT AND METABOLISM OF POLYAMINES IN HUMAN-LYMPHOCYTES

被引：33

作者：

COLOMBATTO, S ^{[1
]}

FASULO, L ^{[1
]}

FULGOSI, B ^{[1
]}

GRILLO, MA ^{[1
]}

机构：

[1] UNIV TURIN,SEZIONE BIOCHIM,DIPARTIMENTO MED & ONCOL SPERIMENTAL,I-10124 TURIN,ITALY

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1990年 / 22卷 / 05期

关键词：

D O I：

10.1016/0020-711X(90)90262-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. Polyamines are taken up by human peripheral lymphocytes in a concentration, time and pH dependent manner, with an energy-dependent transport system. 2. 2. Each polyamine inhibits the uptake of the others, with the exception of putrescine. Spermine appears to have the highest affinity for the transporter/s. 3. 3. Inhibition by ouabain, amyloride and vanadate suggests that the transport is dependent on Na+ 4. 4. Polyamine content inside the cells increases by ca 6 and 3 times respectively during incubation with spermidine or spermine. 5. 5. The incorporated polyamines are partially transformed into each other. © 1990.

引用

页码：489 / 492

页数：4

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