DELAYED CHANGES IN NEURAL VISININ-LIKE CALCIUM-BINDING PROTEIN GENE-EXPRESSION CAUSED BY ACUTE PHENCYCLIDINE ADMINISTRATION

被引：8
|
作者：
KAJIMOTO, Y
SHIRAKAWA, O
KUNO, T
NISHINO, N
NAKAI, H
机构：
[1] KOBE UNIV,SCH MED,DEPT NEUROL & PSYCHIAT,CHUO KU,KOBE 650,JAPAN
[2] KOBE UNIV,SCH MED,DEPT PHARMACOL,CHUO KU,KOBE 650,JAPAN
来源：
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1995年 / 100卷 / 03期
关键词：
PHENCYCLIDINE (PCP); NEURAL VISININ-LIKE CA2+-BINDING PROTEIN (NVP); GENE EXPRESSION; RAT; BRAIN; SCHIZOPHRENIA;
D O I：
10.1007/BF01276463
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia, and PCP-treated animals can serve as a model for schizophrenia. The effects of PCP on the gene expression of NVP-1, a novel Ca2+-binding protein, were studied in rats. After 24 hours, the NVP-1 mRNA level in the nucleus accumbens showed a significant decrease of 42%. This result suggests that alterations in Ca2+-binding protein may be involved in the pathology of PCP-induced psychosis and, presumably, schizophrenia.
引用
收藏
页码：257 / 262
页数：6
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