[TYR(5)]DIDEMNIN-B AND [D-PRO(4)]DIDEMNIN-B - 2 NEW NATURAL DIDEMNINS WITH A MODIFIED MACROCYCLE

被引：14

作者：

ABOUMANSOUR, E ^{[1
]}

BOULANGER, A ^{[1
]}

BADRE, A ^{[1
]}

BONNARD, I ^{[1
]}

BANAIGS, B ^{[1
]}

COMBAUT, G ^{[1
]}

FRANCISCO, C ^{[1
]}

机构：

[1] UNIV PERPIGNAN,CTR PHYTOPHARM,CNRS,URA 461,F-66860 PERPIGNAN,FRANCE

来源：

TETRAHEDRON | 1995年 / 51卷 / 46期

关键词：

D O I：

10.1016/0040-4020(95)00813-N

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structures of the two natural didemnins with a modified macrocycle, [Tyr(5)]didemnin B [2] and [D-Pro(4)]didemnin B [3], isolated from. the Aplousobranch ascidian Trididemnum cyanophorum (Didemnidae) are described. Structures were determined by FABMS and NMR spectroscopy, absolute configurations by Marfey analysis of the acid hydrolisates. Conformational informations are given and cytotoxic activities against human lymphoblastic leukemia cell lines evaluated.

引用

页码：12591 / 12600

页数：10

共 14 条

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