INDUCTION OF AXON GROWTH INTO SCHWANN-CELL IMPLANTS GRAFTED INTO LESIONED ADULT-RAT SPINAL-CORD

被引：115
作者：
PAINO, CL
BUNGE, MB
机构：
[1] UNIV MIAMI,SCH MED,CHAMBERS FAMILY ELECTRON MICROSCOPY LAB,MIAMI,FL 33136
[2] UNIV MIAMI,SCH MED,DEPT CELL BIOL & ANAT,MIAMI,FL 33136
[3] UNIV MIAMI,SCH MED,DEPT NEUROL SURG,MIAMI,FL 33136
来源：
EXPERIMENTAL NEUROLOGY | 1991年 / 114卷 / 02期
关键词：
D O I：
10.1016/0014-4886(91)90043-C
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Polymerized collagen rolls enclosing Schwann cells (SCs) raised in culture were grafted into cystic cavities formed after lesioning the thoracic spinal cord of adult rats. Axons were already present within the graft by 14 days after implantation and both ensheathed and myelinated axons were numerous by 28 days. This axonal ingrowth was maintained over longer survival periods. The axons within the graft always appeared related to Schwann cells. Acellular collagen rolls did not show axonal ingrowth. These Schwann cell-collagen implants resemble peripheral nerve grafts in their ability to induce axonal regeneration into the graft. © 1991.
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页码：254 / 257
页数：4
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