APPLICATION OF SUPERCRITICAL FLUIDS FOR THE PRODUCTION OF SUSTAINED DELIVERY DEVICES

被引：117
作者：
DEBENEDETTI, PG
TOM, JW
YEO, SD
LIM, GB
机构：
[1] Department of Chemical Engineering, Princeton University, Princeton
来源：
JOURNAL OF CONTROLLED RELEASE | 1993年 / 24卷 / 1-3期
关键词：
SUPERCRITICAL FLUID; SUSTAINED DELIVERY DEVICE; RAPID EXPANSION; ANTI-SOLVENT PRECIPITATION;
D O I：
10.1016/0168-3659(93)90166-3
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Supercritical fluids are attractive as vehicles for the formation of particles of biomedical interest. We review two novel techniques: the rapid expansion of supercritical solutions for the formation of solvent-free, drug-loaded, injectable microspheres, and the gas anti-solvent precipitation process for the formation of ultrafine and biologically active protein powders.
引用
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页码：27 / 44
页数：18
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