AN EFFICIENT ASYMMETRIC-SYNTHESIS OF (R)-3-AMINO-2,3,4,5-TETRAHYDRO-1H-[1]BENZAZEPIN-2-ONE

被引：45

作者：

ARMSTRONG, JD

ENG, KK

KELLER, JL

PURICK, RM

HARTNER, FW

CHOI, WB

ASKIN, D

VOLANTE, RP

机构：

[1] Department of Process Research Merck Research Laboratories, Rahway, NJ 07065-0900

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)76874-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two approaches for the asymmetric preparation of (-)- or (+)- alpha-aminobenzlactam 1 are described. One route is based on the asymmetric hydrogenation of enamide 5 and the other on the racemization/resolution of (+/-)-1.

引用

页码：3239 / 3242

页数：4

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