POTENTIAL ANTIATHEROSCLEROTIC AGENTS .5. AN ACYL-COA - CHOLESTEROL O-ACYLTRANSFERASE INHIBITOR WITH HYPOCHOLESTEROLEMIC ACTIVITY

被引:48
作者
DEVRIES, VG
SCHAFFER, SA
LARGIS, EE
DUTIA, MD
WANG, CH
BLOOM, JD
KATOCS, AS
机构
关键词
D O I
10.1021/jm00157a002
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1131 / 1133
页数:3
相关论文
共 50 条
[21]   Synthesis and structure-activity relationship studies on a novel series of naphthylidinoylureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) [J].
Ohnuma, S ;
Muraoka, M ;
Ioriya, K ;
Ohashi, N .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (05) :1309-1311
[22]   INHIBITORS OF ACYL-COA-CHOLESTEROL O-ACYLTRANSFERASE (ACAT) AS HYPOCHOLESTEROLEMIC AGENTS .14. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A NOVEL SERIES OF SULFONAMIDE TETRAZOLES [J].
LEE, HT ;
SLISKOVIC, DR ;
STANFIELD, RL ;
HAMELEHLE, KL ;
BOUSLEY, RF ;
KRAUSE, BR .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (03) :301-306
[23]   Total synthesis of acyl-CoA: Cholesterol acyltransferase inhibitor beauveriolide I [J].
Tian, Hua ;
Jiao, Xiao-Zhen ;
Xie, Ping ;
Liang, Xiao-Tian .
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2007, 27 (01) :103-108
[24]   Isolation of acyl-CoA:cholesterol acyltransferase inhibitor from Persicaria vulgaris [J].
Song, HY ;
Rho, MC ;
Lee, SW ;
Kwon, OE ;
Chang, YD ;
Lee, HS ;
Kim, YK .
PLANTA MEDICA, 2002, 68 (09) :845-847
[25]   Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors [J].
Shibuya, Kimiyuki ;
Kawamine, Katsumi ;
Miura, Toru ;
Ozaki, Chiyoka ;
Edano, Toshiyuki ;
Mizuno, Ken ;
Yoshinaka, Yasunobu ;
Tsunenari, Yoshihiko .
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (14) :4001-4013
[26]   INHIBITION OF ACYL-COA CHOLESTEROL O-ACYLTRANSFERASE REDUCES THE CHOLESTERYL ESTER ENRICHMENT OF ATHEROSCLEROTIC LESIONS IN THE YUCATAN MICROPIG [J].
BOCAN, TMA ;
MUELLER, SB ;
UHLENDORF, PD ;
BROWN, EQ ;
MAZUR, MJ ;
BLACK, AE .
ATHEROSCLEROSIS, 1993, 99 (02) :175-186
[27]   FCE 27677: A novel inhibitor of acyl-CoA:cholesterol acyltransferase with potent oral hypolipidemic activity [J].
Chiari, A ;
Lovisolo, P ;
Radice, A ;
Giorgini, L ;
Fancelli, D ;
Severino, D ;
Ghiselli, G .
PHARMACOLOGICAL RESEARCH, 1995, 32 (04) :189-199
[28]   DEFECTIVE ACTIVITY OF ACYL-COA - CHOLESTEROL O-ACYLTRANSFERASE IN NIEMANN-PICK TYPE-C AND TYPE-D FIBROBLASTS [J].
BYERS, DM ;
RASTOGI, SR ;
COOK, HW ;
PALMER, FBS ;
SPENCE, MW .
BIOCHEMICAL JOURNAL, 1989, 262 (03) :713-719
[29]   Inhibition of Acyl-CoA cholesterol acyltransferase by F12511 (Eflucimibe):: Could it be a new antiatherosclerotic therapeutic? [J].
Jose Lopez-Farre, Antonio ;
Sacristan, Daniel ;
Zamorano-Leon, Jose J. ;
San-Martin, Nuria ;
Macaya, Carlos .
CARDIOVASCULAR THERAPEUTICS, 2008, 26 (01) :65-74
[30]   Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. The synthesis and biological activity of a series of malonester amides [J].
Sliskovic, DR ;
Picard, JA ;
Roark, WH ;
Essenburg, AD ;
Krause, BR ;
Minton, LL ;
Reindel, JF ;
Stanfield, RL .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (06) :713-718