RADIATION ENHANCED REACTIVATION OF HERPES-SIMPLEX VIRUS - EFFECT OF CAFFEINE

被引：18
作者：
HELLMAN, KB [1 ]
LYTLE, CD [1 ]
BOCKSTAHLER, LE [1 ]
机构：
[1] US FDA, BUR RADIOL HLTH, ROCKVILLE, MD 20852 USA
来源：
MUTATION RESEARCH | 1976年 / 36卷 / 03期
关键词：
D O I：
10.1016/0027-5107(76)90234-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
UV enhanced (Weigle) reactivation of UV-irradiated herpes simplex virus in UV-irradiated CV-1 [African green] monkey kidney cells was decreased by caffeine. X-ray enhanced reactivation of UV-irradiated virus in X-irradiated monolayers (X-ray reactivation) and UV- or X-ray-inactivated capacity of the cells to support unirradiated virus plaque formation were unaffected by caffeine. A caffeine-sensitive process in probably necessary for the expression of Weigle reactivation for herpesvirus. Since caffeine did not significantly affect X-ray reactivation, different mechanisms may be responsible for the expression of Weigle reactivation and X-ray reactivation.
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页码：249 / 255
页数：7
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