AMPICILLIN-SULBACTAM VERSUS AMPICILLIN ALONE FOR CESAREAN-SECTION PROPHYLAXIS - A RANDOMIZED DOUBLE-BLIND TRIAL

被引：9
作者：
RIJHSINGHANI, A [1 ]
SAVOPOULOS, SE [1 ]
WALTERS, JK [1 ]
HUGGINS, G [1 ]
HIBBS, JR [1 ]
机构：
[1] FRANCIS SCOTT KEY MED CTR,BALTIMORE,MD 21224
来源：
AMERICAN JOURNAL OF PERINATOLOGY | 1995年 / 12卷 / 05期
关键词：
SULBACTAM; AMPICILLIN; PROPHYLAXIS; CESAREAN SECTION; RUPTURE OF MEMBRANES;
D O I：
10.1055/s-2007-994485
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
To study the effectiveness of anaerobic coverage in prevention of postpartum endometritis in women undergoing nonelective cesarean sections, we conducted a randomized prospective double-blind study of women undergoing cesarean sections and requiring antibiotic prophylaxis from April 1, 1989, through December 31, 1990. Ninety-four patients were enrolled in the study. Forty-five patients received ampicillin alone and 46 received ampicillin in conjunction with sulbactam. All patients were evaluated prior to surgery and in the postoperative period. Ninety-one patients completed the study and their records were analyzed. Patients were divided into two groups depending on the presence or absence of ruptured membranes. Seventy-five percent of patients had ruptured membranes. Failure of prophylaxis and subsequent endometritis was documented in 8.8% of patients who received ampicillin and sulbactam and 35.3% of patients who received ampicillin alone. This difference was statistically significant (p <0.02). In conclusion, single-dose ampicillin and sulbactam provides better prophylaxis than single-dose ampicillin in women undergoing cesarean section with rupture of membranes.
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页码：322 / 324
页数：3
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