EVALUATION OF A RECOMBINANT PARASITE ANTIGEN FOR THE DIAGNOSIS OF LYMPHATIC FILARIASIS

被引:22
作者
DISSANAYAKE, S
ZHENG, HJ
DREYER, G
XU, M
WATAWANA, L
CHENG, GH
WANG, SH
MORIN, P
DENG, BJ
KURNIAWAN, L
VINCENT, A
PIESSENS, WF
机构
[1] GUIZHOU PROV INST PARASIT DIS,DEPT FILARIASIS,GUIYANG,PEOPLES R CHINA
[2] FIOCRUZ MS,AGGEU MAGALHAES RES CTR,DEPT PARASITOL,RECIFE,PE,BRAZIL
[3] FAC MED PERADENIYA,PERADENIYA,SRI LANKA
[4] SHANGHAI MED UNIV,DEPT PARASITOL,SHANGHAI 200032,PEOPLES R CHINA
[5] NATL INST HLTH RES & DEV,JAKARTA,INDONESIA
[6] UNIV S FLORIDA,DEPT MED,TAMPA,FL 33612
关键词
D O I
10.4269/ajtmh.1994.50.727
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
We evaluated the usefulness of a recombinant parasite antigen (recSXP1) for the serologic diagnosis of lymphatic filariasis. A large proportion of sera from microfilaremic donors living in five different endemic countries (356 of 446 [80%]) contained IgG antibodies to recSXP1, as do sera from similar to 33% of amicrofilaremic patients with acute filarial disease and/or indirect evidence of active filarial infection. Exposure to filarial worms per se does not appear sufficient to elicit an anti-SXP1 antibody response. Thus, this serologic test identifies a large proportion of persons with active lymphatic filariasis among residents of endemic areas.
引用
收藏
页码:727 / 734
页数:8
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