EFFECTS OF CORTISOL ON BLOOD-PRESSURE AND SALT PREFERENCE IN NORMAL HUMANS

被引：13

作者：

WONG, KS

WILLIAMSON, PM

BROWN, MA

ZAMMIT, VC

DENTON, DA

WHITWORTH, JA

机构：

[1] UNIV NEW S WALES, ST GEORGE HOSP, DEPT RENAL MED, SYDNEY, NSW, AUSTRALIA

[2] UNIV NEW S WALES, ST GEORGE HOSP, DEPT MED, SYDNEY, NSW, AUSTRALIA

[3] UNIV MELBOURNE, HOWARD FLOREY INST EXPTL PHYSIOL & MED, PARKVILLE, VIC 3052, AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1993年 / 20卷 / 02期

关键词：

HYDROCORTISONE; HYPERTENSION; SALT PREFERENCE; SALT TASTE; TASTE INTENSITY;

D O I：

10.1111/j.1440-1681.1993.tb00584.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Adrenocorticotrophic hormone (ACTH) and corticosteroids stimulate salt appetite in laboratory animals. The hypothesis tested was that cortisol administration increases salt preference in humans 2. Sodium taste studies (detection and recognition thresholds, taste intensity and preference tests) were conducted before, during and after cortisol administration (200 mg/day for 5 days) in normal men on a free diet. 3. Cortisol significantly increased systolic blood pressure (SBP), 113+/-3-130+/-4 mmHg, P<0.05; diastolic blood pressure (DBP), 65+/-3-81+/-2 mmHg, P<0.05; mean arterial pressure (MAP), 81+/-2-97+/-3 mmHg, P<0.05; and bodyweight, 72.9+/-3.0-75.4+/-3.3 kg, P<0.05. 4. Salt detection and recognition thresholds, taste intensity and preference for sodium chloride were unchanged following cortisol.

引用

页码：121 / 126

页数：6

共 25 条

[11] STUDIES ON TASTE THRESHOLDS IN NORMAL MAN AND IN PATIENTS WITH ADRENAL CORTICAL INSUFFICIENCY - ROLE OF ADRENAL CORTICAL STEROIDS AND OF SERUM SODIUM CONCENTRATION [J].