PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES - ANTISENSE INHIBITORS OF GENE-EXPRESSION

被引：116
作者：
STEIN, CA [1 ]
TONKINSON, JL [1 ]
YAKUBOV, L [1 ]
机构：
[1] NOVOSIBIRSK BIOORGAN CHEM INST, NOVOSIBIRSK, USSR
来源：
PHARMACOLOGY & THERAPEUTICS | 1991年 / 52卷 / 03期
关键词：
D O I：
10.1016/0163-7258(91)90032-H
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Phosphorothioate (PS) oligodeoxynucleotides are relatively nuclease resistant, water soluble analogs of phosphodiester (PO) oligodeoxynucleotides. These molecules are chiral but still hybridize well to their RNA targets. While considered for use as in vivo anti-sense inhibitors of gene expression, their biology, especially in the anti-viral area, is dominated by non-sequence specific effects. This review discusses both the sequence and non-sequence specific biologic effects of PS oligomers, and attempts to more clearly indicate their ultimate therapeutic potential.
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页码：365 / 384
页数：20
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