COMPARATIVE IMMUNOHISTOCHEMICAL STUDY OF 4 MONOCLONAL-ANTIBODIES DIRECTED AGAINST OVARIAN CARCINOMA-ASSOCIATED ANTIGENS

被引:68
|
作者
BOERMAN, OC
VANNIEKERK, CC
MAKKINK, K
HANSELAAR, TGJM
KENEMANS, P
POELS, LG
机构
[1] CATHOLIC UNIV NIJMEGEN,DEPT CELL BIOL & HISTOL,POB 9101,6500 HB NIJMEGEN,NETHERLANDS
[2] CATHOLIC UNIV NIJMEGEN,DEPT PATHOL,6500 HB NIJMEGEN,NETHERLANDS
[3] FREE UNIV AMSTERDAM,DEPT OTOLARYNGOL,1007 MC AMSTERDAM,NETHERLANDS
关键词
MONOCLONAL ANTIBODIES; OVARIAN CARCINOMA; IMMUNOHISTOCHEMISTRY;
D O I
10.1097/00004347-199101000-00002
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The monoclonal antibodies OC 125, OV-TL 3, MOv 18, and OV-TL 23, which are directed against distinct ovarian carcinoma-associated antigens, are assessed in the present study for their diagnostic value. The expression of the antigens defined by these was studied in serial sections from 80 ovarian carcinomas and 103 nonovarian carcinomas obtained from 183 patients, using the immunoperoxidase technique. Immunoelectron microscopy demonstrated that the antigens were all localized on the tumor cell membrane. OC 125, OV-TL 3, and MOv 18 reacted positively with approximately-90% of the ovarian carcinoma samples (n = 80), whereas OV-TL 23 stained 76% of these samples. OC 125, OV-TL 3, and MOv 18 were also reactive with a majority of carcinomas derived from the cervix, endometrium and fallopian tube, while OV-TL 23 reactivity was primarily restricted to ovarian carcinomas. OC 125 and OV-TL 3 reacted respectively with 11% and 14% of the nongynecologic carcinomas tested (n = 64). Positive cases included breast, colon, and lung carcinomas. The antibodies MOv 18 and OV-TL 23 were found less reactive with nongynecologic carcinomas.
引用
收藏
页码:15 / 25
页数:11
相关论文
共 50 条
  • [31] MURINE HYBRIDOMA ANTIBODIES AGAINST HUMAN TRANSITIONAL CARCINOMA-ASSOCIATED ANTIGENS
    MESSING, EM
    BUBBERS, JE
    WHITMORE, KE
    DEKERNION, JB
    NESTOR, MS
    FAHEY, JL
    JOURNAL OF UROLOGY, 1984, 132 (01): : 167 - 172
  • [32] MONOCLONAL-ANTIBODIES REACTIVE WITH THE BREAST CARCINOMA-ASSOCIATED MUCIN CORE PROTEIN REPEAT SEQUENCE PEPTIDE ALSO RECOGNIZE THE OVARIAN CARCINOMA-ASSOCIATED SEBACEOUS GLAND ANTIGEN
    LAYTON, GT
    DEVINE, PL
    WARREN, JA
    BIRRELL, G
    XING, PX
    WARD, BG
    MCKENZIE, IFC
    TUMOR BIOLOGY, 1990, 11 (05) : 274 - 286
  • [33] PRODUCTION OF MURINE MONOCLONAL-ANTIBODIES AGAINST CELL-SURFACE ANTIGENS OF HUMAN OVARIAN-CARCINOMA
    BHATTACHARYA, M
    CHATTERJEE, SK
    GANGOPADHYAY, A
    BARLOW, JJ
    JOURNAL OF SURGICAL ONCOLOGY, 1985, 30 (04) : 209 - 214
  • [34] MONOCLONAL-ANTIBODIES DIRECTED AGAINST HUMAN AIRWAY SECRETIONS - LOCALIZATION AND CHARACTERIZATION OF ANTIGENS
    FINKBEINER, WE
    BASBAUM, CB
    AMERICAN JOURNAL OF PATHOLOGY, 1988, 131 (02): : 290 - 297
  • [35] DETERMINATION OF THE IMMUNOREACTIVE FRACTION OF RADIOLABELED MONOCLONAL-ANTIBODIES DIRECTED AGAINST INTRACELLULAR ANTIGENS
    HAISMA, HJ
    PINEDO, HM
    SILVA, CA
    BOVEN, E
    JOURNAL OF IMMUNOLOGICAL METHODS, 1992, 154 (01) : 55 - 60
  • [36] IMMUNOHISTOCHEMICAL ANALYSIS OF THE SPECIFICITY OF MONOCLONAL-ANTIBODIES RAISED AGAINST CARCINOMA OF THE PROSTATE
    WIRTH, M
    ORMANNS, W
    PROSTATE, 1985, 6 (04): : 449 - 449
  • [38] MONOCLONAL-ANTIBODIES RAISED AGAINST NEUAC-ALPHA-2-6NEOLACTOTETRAOSYLCERAMIDE DETECT CARCINOMA-ASSOCIATED GANGLIOSIDES
    NILSSON, O
    LINDHOLM, L
    HOLMGREN, J
    SVENNERHOLM, L
    BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 835 (03) : 577 - 583
  • [39] IMMUNOHISTOLOGICAL STUDY OF ULCERATIVE-COLITIS WITH MONOCLONAL-ANTIBODIES AGAINST TUMOR ASSOCIATED ANTIGENS
    COOPER, HS
    STEPLEWSKI, Z
    LABORATORY INVESTIGATION, 1986, 54 (01) : A13 - A13
  • [40] IMMUNORADIODETECTION OF CIRCULATING TUMOR ASSOCIATED ANTIGENS IN PATIENTS WITH OVARIAN-CARCINOMA USING MURINE MONOCLONAL-ANTIBODIES
    MIOTTI, S
    CANEVARI, S
    LEONI, F
    DIOTTI, A
    ORLANDI, R
    COLNAGHI, MI
    EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1985, 21 (11): : 1402 - 1402