Inflammation in Depression: The Role of Cytokines

被引：0

作者：

Gumru, Salih

Aricioglu, Feyza ^{[1
,2
]}

机构：

[1] Marmara Univ, Sch Pharm, Dept Pharmacol, TR-34668 Istanbul, Turkey

[2] Marmara Univ, Psychopharmacol Res Unit, TR-34668 Istanbul, Turkey

来源：

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES | 2012年 / 2卷 / 03期

关键词：

Cytokine; inflammation; depression; antidepressant;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Recent studies support the concept that inflammatory mechanisms play a crucial role in the pathomechanisms of major depression. Major depression shares similarities with 'sickness behavior', a normal response to inflammatory cytokines. Elevations in proinflammatory cytokines and other inflammation-related proteins in major depression were found in plasma and cerebrospinal fluid (CSF). Clinical progress of the disease may also be predicted by the changes in proinflammatory cytokine levels. Antidepressant treatment can lead to a normalization of elevated cytokine levels in major depression. The new hypothesis of depression provided some new opportunities in treatment of depression.

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页码：103 / 107

页数：5

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