Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies

被引：21

作者：

Kelsoe, Garnett ^{[1
,2
]}

Verkoczy, Laurent ^{[1
,2
,3
]}

Haynes, Barton F. ^{[1
,2
,3
]}

机构：

[1] Duke Univ, Sch Med, Dept Immunol, Durham, NC 27710 USA

[2] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27710 USA

[3] Duke Univ, Sch Med, Dept Med, Durham, NC 27710 USA

来源：

VACCINES | 2014年 / 2卷 / 01期

关键词：

HIV-1; vaccines; immune tolerance; broadly neutralizing antibody; B-cell lineage design; HIV-1 vaccine strategy;

D O I：

10.3390/vaccines2010001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this brief review, we discuss immune tolerance as a factor that determines the magnitude and quality of serum antibody responses to HIV-1 infection and vaccination in the context of recent work. We propose that many conserved, neutralizing epitopes of HIV-1 are weakly immunogenic because they mimic host antigens. In consequence, B cells that strongly bind these determinants are removed by the physiological process of immune tolerance. This structural mimicry may represent a significant impediment to designing protective HIV-1 vaccines, but we note that several vaccine strategies may be able to mitigate this evolutionary adaptation of HIV and other microbial pathogens.

引用

页码：1 / 14

页数：14

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