COMPARISON BETWEEN NALOXONE REVERSAL OF MORPHINE AND ELECTRICAL-STIMULATION INDUCED ANALGESIA IN RAT MESENCEPHALON

被引：98

作者：

PERT, A ^{[1
]}

WALTER, M ^{[1
]}

机构：

[1] NIMH, ADULT PSYCHIAT BRANCH, BETHESDA, MD 20014 USA

来源：

LIFE SCIENCES | 1976年 / 19卷 / 07期

关键词：

D O I：

10.1016/0024-3205(76)90294-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Comparisons were made between the efficacy of naloxone to reverse analgesia induced by electrical stimulation (SPA) of the periaqueductal gray matter and analgesia induced by microinjections of morphine into the same brain region. Naloxone at 1 or 10 mg/kg was ineffective in antagonizing SPA during the 1st 2 min post-stimulation. Although some antagonism did appear 3-5 min after stimulation, the effect was neither consistent nor dose-dependent. Morphine was antagonized in a dose-dependent and complete fashion by naloxone. The assumption that similar mechanisms underlie both opiate and electrical stimulation induced analgesia is discussed.

引用

页码：1023 / 1032

页数：10

共 35 条

[1] ANTAGONISM OF STIMULATION-PRODUCED ANALGESIA BY NALOXONE, A NARCOTIC-ANTAGONIST [J].