The GC factor regulates the expression of the insulin-like growth factor-I receptor

被引：5

作者：

Morrione, A ^{[1
]}

DeAngelis, T ^{[1
]}

Baserga, R ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV,JEFFERSON CANC CTR,PHILADELPHIA,PA 19107

来源：

CELL PROLIFERATION | 1995年 / 28卷 / 12期

关键词：

D O I：

10.1111/j.1365-2184.1995.tb00052.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have transfected a plasmid expressing the transcriptional regulator GC Factor (GCF) into cell lines and have found that the GCF: 1 causes a decrease in the levels of insulin-like growth factor I receptor (IGF-IR) mRNA; 2 causes a decrease in the number of IGF-IRs; and 3 represses the activity of the IGF-IR promoter. In addition, we show that the regulation of IGF-IR expression by GCF plays a physiological role in the control of cellular proliferation in vitro.

引用

页码：659 / 671

页数：13

共 58 条

[1] GROWTH-REGULATION OF HUMAN GLIOBLASTOMA T98G CELLS BY INSULIN-LIKE GROWTH-FACTOR-I AND ITS RECEPTOR [J].

AMBROSE, D ;

RESNICOFF, M ;

COPPOLA, D ;

SELL, C ;

MIURA, M ;

JAMESON, S ;

BASERGA, R ;

RUBIN, R .

JOURNAL OF CELLULAR PHYSIOLOGY, 1994, 159 (01) :92-100

[2] INTERFERENCE OF THE IGF SYSTEM AS A STRATEGY TO INHIBIT BREAST-CANCER GROWTH [J].

ARTEAGA, CL .

BREAST CANCER RESEARCH AND TREATMENT, 1992, 22 (01) :101-106

[3]

BAKER J, 1993, CELL, V75, P73, DOI 10.1016/0092-8674(93)90680-O

[4]

BASERGA R, 1995, CANCER RES, V55, P249

[5] THE ROLE OF THE IGF-I RECEPTOR IN THE GROWTH AND TRANSFORMATION OF MAMMALIAN-CELLS [J].

BASERGA, R ;

SELL, C ;

PORCU, P ;

RUBINI, M .

CELL PROLIFERATION, 1994, 27 (02) :63-71

[6]

Baserga Renato, 1993, Critical Reviews in Eukaryotic Gene Expression, V3, P47

[7]

BEGUINOT L, 1995, CELL GROWTH DIFFER, V6, P699

[8] A 2ND SIGNAL SUPPLIED BY INSULIN-LIKE GROWTH-FACTOR-II IN ONCOGENE-INDUCED TUMORIGENESIS [J].

CHRISTOFORI, G ;

NAIK, P ;

HANAHAN, D .

NATURE, 1994, 369 (6479) :414-418

[9] VARIABLES CONTROLLING SOMATOMEDIN PRODUCTION BY CULTURED HUMAN-FIBROBLASTS [J].

CLEMMONS, DR ;

SHAW, DS .

JOURNAL OF CELLULAR PHYSIOLOGY, 1983, 115 (02) :137-142

[10]

CLEMMONS DR, 1981, TISSUE GROWTH FACTOR, P161

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