Nuclear imaging in detection and monitoring of cardiotoxicity

被引:23
作者
D'Amore, Carmen [1 ]
Gargiulo, Paola [2 ]
Paolillo, Stefania [1 ]
Pellegrino, Angela Maria [1 ]
Formisano, Tiziana [1 ]
Mariniello, Antonio [1 ]
Della Ratta, Giuseppe [1 ]
Iardino, Elisabetta [1 ]
D'Amato, Marianna [1 ]
La Mura, Lucia [1 ]
Fabiani, Irma [1 ]
Fusco, Flavia [1 ]
Filardi, Pasquale Perrone [1 ]
机构
[1] Univ Naples Federico II, Dept Adv Biomed Sci, Via Pansini 5, I-80131 Naples, Italy
[2] SDN Fdn, Inst Diagnost & Nucl Dev, I-80129 Naples, Italy
来源
WORLD JOURNAL OF RADIOLOGY | 2014年 / 6卷 / 07期
关键词
Cardiotoxicity; Cardiac nuclear imaging; Early diagnosis; Scintigraphy; Positron emission tomography;
D O I
10.4329/wjr.v6.i7.486
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient's management and outcome. The coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor agents. Left ventricular dysfunction is the most typical manifestation and can lead to heart failure. Left ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage, but it identifies a late manifestation of myocardial injury. Early non-invasive imaging techniques are needed for the diagnosis and monitoring of cardiotoxic effects. Although echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment, greater attention is focused on new nuclear cardiologic techniques, which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical manifestation. The aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage, focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity. (c) 2014 Baishideng Publishing Group Inc. All rights reserved.
引用
收藏
页码:486 / 492
页数:7
相关论文
共 50 条
[11]   Type II chemotherapy-related cardiac dysfunction: Time to recognize a new entity [J].
Ewer, MS ;
Lippman, SM .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (13) :2900-2902
[12]   The Utility of Cardiac Biomarkers, Tissue Velocity and Strain Imaging, and Cardiac Magnetic Resonance Imaging in Predicting Early Left Ventricular Dysfunction in Patients With Human Epidermal Growth Factor Receptor II-Positive Breast Cancer Treated With Adjuvant Trastuzumab Therapy [J].
Fallah-Rad, Nazanin ;
Walker, Jonathan R. ;
Wassef, Anthony ;
Lytwyn, Matthew ;
Bohonis, Sheena ;
Fang, Tielan ;
Tian, Ganhong ;
Kirkpatrick, Iain D. C. ;
Singal, Pawan K. ;
Krahn, Marianne ;
Grenier, Debjani ;
Jassal, Davinder S. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 57 (22) :2263-2270
[13]   Delayed contrast enhancement cardiac magnetic resonance imaging in trastuzumab induced cardiomyopathy [J].
Fallah-Rad, Nazanin ;
Lytwyn, Matthew ;
Fang, Tielan ;
Kirkpatrick, Iain ;
Jassal, Davinder S. .
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2008, 10 (1)
[14]   THE AUTONOMIC NERVOUS-SYSTEM IN CONGESTIVE-HEART-FAILURE [J].
FRANCIS, GS ;
COHN, JN .
ANNUAL REVIEW OF MEDICINE, 1986, 37 :235-247
[15]  
Groch MW, 2001, J NUCL MED, V42, P1773
[16]   Clinical validation of the gated blood pool SPECT QBSS® processing software in congestive heart failure patients:: correlation with MUGA, first-pass RNV and 2D-echocardiography [J].
Hacker, M ;
Hoyer, X ;
Kupzyk, S ;
La Fougere, C ;
Kois, J ;
Stemp, HU ;
Tiling, R ;
Hahn, K ;
Störk, S .
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 2006, 22 (3-4) :407-416
[17]   Regional patterns of myocardial sympathetic denervation in dilated cardiomyopathy: an analysis using carbon-11 hydroxyephedrine and positron emission tomography [J].
Hartmann, F ;
Ziegler, S ;
Nekolla, S ;
Hadamitzky, M ;
Seyfarth, M ;
Richardt, G ;
Schwaiger, M .
HEART, 1999, 81 (03) :262-270
[18]   ACCF/ACR/SCCT/SCMR/ASNC/NASCI/SCAI/SIR 2006 appropriateness criteria for cardiac computed tomography and cardiac magnetic resonance imaging - A report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group, American College of Radiology, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, American Society of Nuclear Cardiology, North American Society for Cardiac Imaging, Society for Cardiovascular Angiography and Interventions, and Society of Interventional Radiology [J].
Hendel, Robert C. ;
Patel, Manesh R. ;
Kramer, Christopher M. ;
Poon, Michael ;
Hendel, Robert C. ;
Brindis, Ralph G. ;
Hendel, Robert C. ;
Douglas, Pamela S. ;
Peterson, Eric D. ;
Wolk, Michael J. ;
Allen, Joseph M. ;
Patel, Manesh R. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (07) :1475-1497
[19]   EANM/ESC guidelines for radionuclide imaging of cardiac function [J].
Hesse, B. ;
Lindhardt, T. B. ;
Acampa, W. ;
Anagnostopoulos, C. ;
Ballinger, J. ;
Bax, J. J. ;
Edenbrandt, L. ;
Flotats, A. ;
Germano, G. ;
Stopar, T. Gmeiner ;
Franken, P. ;
Kelion, A. ;
Kjaer, A. ;
Le Guludec, D. ;
Ljungberg, M. ;
Maenhout, A. F. ;
Marcassa, C. ;
Marving, J. ;
McKiddie, F. ;
Schaefer, W. M. ;
Stegger, L. ;
Underwood, R. .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2008, 35 (04) :851-885
[20]  
Hwang HJ, 2010, CLIN CARDIOL, V33, pE69, DOI [10.1002/clc.20725, 10.1002/clc.20567]